Magnesium: An Introduction to its Supramolecular Chemistry and Biology

  • T. Theophanides
  • J. Anastassopoulou
  • G. De Munno
  • J. Durlach
  • M. Bara


Despite the major advances of magnesium research during the past 20 years, there is still much to be learned about the mechanism of action of magnesium cations in the many chemical and biological processes in which the water molecules are intimately involved. Very little systematic study has been conducted of magnesium chemicals that may inhibit or prevent cancer. The effect of counter anion also has not been studied to its basic considerations and magnesium ions in cardiovascular cells. The supramolecular chemistry of magnesium in biological systems is the starting point of description of the chemistry and biochemistry of magnesium. Magnesium ions are present in all cells and in all reactions in which ATP is a substrate (Mg2+.ATP)[1]. In this substrate complex, Mg2+ is chelated between the phosphates β and γ and is capable of approaching and bind in a reversible fashion to other sites of specific proteins. However, its precise function in the specific cleavage of the terminal phosphoryl group of the ATP molecule is still unknown [2]. In addition, it intervenes in all the nucleic acid syntheses, in nucleotides or lipids and glucides and in the activation of muscular contraction. This cleavage involves hydrolysis of ATP to ADP and Pi and Mg2+ is known to be essential for this dephosphorylation. The hydrolysis of ATP at the Pγ position has not been determined clearly. It proceeds through the attack of nucleophiles, such as OH− and H2O on the Pγ


Supramolecular Chemistry Magnesium Sulphate Counter Anion Nucleic Acid Synthesis Specific Cleavage 
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  1. 1.
    Szent-Gyoergyi, A. (1956) in O.H. Gaebler (ed.), Enzymes: Units of biological structure and function, Academic Press, New York, p. 393.Google Scholar
  2. 2.
    Yokshikawa, K., Shinohara, Y., Terada, H., Kato, S. (1987) Why is Mg2+ necessary for specific cleavage of the terminal phosphoryl group of ATP?, Biophs. Chem., 27, 251–254.CrossRefGoogle Scholar
  3. 3.
    Anastassopoulou, J., Andreopoulos, A.G., Theophanides, T. (1996), The interactions of magnesium salts with water in biological systems, in M J Halpem & J Durlach, (eds.), Current Research in Magnesium, John Libbey, London, Chap 33, p. 137–140Google Scholar
  4. 4.
    Williams, R.J.P., Magnesium: An introduction to its biochemistry, (1993), in N.J. Birch (ed.), Academic Press, New York, p. 15Google Scholar
  5. 5.
    Gaday, M.A., De Munno, G., Mrdaglia, M., Anastassopoulou, J., Theophanides, T. (1997) First Isolation of Supramolecular Assemblies containing Nucleic Bases and Magnesium (II) Hexahydrate Ions, Angewante Chemie, Int. Ed. Engl., 36, 511.CrossRefGoogle Scholar
  6. 6.
    Theophanides, T. (1996), Biological Implications of Magnesium Salt at the Molecular Level, Magnesium Res., 9, 259.Google Scholar
  7. 7.
    Durlach, J., Bara, M., Theophanides, T. (1996), A hint on pharmacological and toxicological Differences Between Magnesium Chloride and Magnesium Sulphate, or of Scallops and Men, Magnesium Res., 9, 217–219.Google Scholar
  8. 8.
    Teeter, M.M., Quigley, G.I., Rich, A. (1980), Metal ions and transfer RNA, in T.G. Spiro, ed., Nucleic acid-metal ion interactions, John Willey and Sons, New York, Chapt. 4., pp. 145–177.Google Scholar
  9. 9.
    Armentano, D., De Munno, G., Regina, M., Anastassopoulou, J., Theophanides, T. (1997), Supramolecular Mg (II) complexes of cytosine and 1-methylcytosine, in T. Theophanides, J. Anastassopoulou, eds., Magnesium: Current status and new developments, Kluwer Academic Publishers, The Netherlands, this volume.Google Scholar
  10. 10.
    Theophanides, T., Angiboust, J-F., Polissiou, M, Anastassopoulou, J., Manfait, M. (1990), Possible role of water structure in biological magnesium systems, Magnesium Res., 3, 5–13.Google Scholar

Copyright information

© Kluwer Academic Publishers 1997

Authors and Affiliations

  • T. Theophanides
    • 1
  • J. Anastassopoulou
    • 1
  • G. De Munno
    • 2
  • J. Durlach
    • 3
  • M. Bara
    • 3
  1. 1.Chemical Engineering Department, Radiation Chemistry and BiospectroscopyNational Technical University of AthensZografouAthensGreece
  2. 2.Dipartimento di ChimicaUniversità della CalabriaArcavacata di Rende, ConsenzaItaly
  3. 3.S.D.R.M. Hopital Saint Vincent de PaulParisFrance

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