Are C-Reactive Protein and Fibrinogen Risk Factors?
Part of the
Developments in Cardiovascular Medicine
book series (DICM, volume 197)
The function of haemostasis components in the cause and progression of atherosclerosis gained considerable interest since a study by de Wood et al.1 who showed the importance of coronary obstruction by thrombi and an epidemiological study by Meade et al.2 who found that fibrinogen and a few other haemostasis parameters indicated the risk of a coronary event in a healthy population. In the years which followed several haemostasis components in blood, including platelet, coagulation and fibrinolysis factors, were found to have a different concentration from normals in individuals at cardiovascular risk. As most, if not all, changes of levels pointed towards a hypercoagulable state in stroke, coronary disease or peripheral atherosclerosis, the rationale of the association between haemostasis and cardiovascular disease in prospective studies seems to be obvious: a change in levels of a haemostatic parameter triggers arterial thrombosis, a key factor in the etiology of cardiovascular disease. Out of all the haemostatic risk factors, fibrinogen has a dominant place. It has been repeatedly found to be a risk factor in stroke, coronary heart disease and peripheral atherosclerosis.3 Moreover, in contrast to other haemostatic risk factors, it is gradually correlated to the extent of the atherosclerosis as determined by coronary angiography4 or ultrasound techniques.5
KeywordsCoronary Event Angina Pecteris Include Smoking Status Peripheral Atherosclerosis European Concert Action
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© Kluwer Academic Publishers 1997