Raman Spectroscopy during Catheterization: A Means of Viewing Plaque Composition

  • Tjeerd J. Römer
  • James F. BrennanIII
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 197)


The progression and regression of atherosclerotic plaques appear to be related to the amount and type of lipids that accumulate in the intima of arteries.1–3 Recent studies have shown that plaque composition, rather than size or volume, determines whether an arterial narrowing will rupture and cause an acceleration of clinical symptoms.4,5 Clearly, an instrument is needed that can determine in situ the chemical composition of atherosclerotic lesions objectively and accurately. Raman spectroscopy is a powerful technique, capable of providing detailed, quantitative information about the chemical composition of arterial wall non-destructively. Such an instrument would be useful to clinicians and researchers in many applications, such as predicting plaque rupture and selecting proper therapeutic interventions. In this chapter, a review is given of the basic principles and potential applications of Raman spectroscopy.


Raman Spectrum Raman Spectroscopy Calcify Plaque Scattered Photon Calcium Salt 
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© Kluwer Academic Publishers 1997

Authors and Affiliations

  • Tjeerd J. Römer
  • James F. BrennanIII

There are no affiliations available

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