Raman Spectroscopy during Catheterization: A Means of Viewing Plaque Composition

  • Tjeerd J. Römer
  • James F. BrennanIII
Part of the Developments in Cardiovascular Medicine book series (DICM, volume 197)

Abstract

The progression and regression of atherosclerotic plaques appear to be related to the amount and type of lipids that accumulate in the intima of arteries.1–3 Recent studies have shown that plaque composition, rather than size or volume, determines whether an arterial narrowing will rupture and cause an acceleration of clinical symptoms.4,5 Clearly, an instrument is needed that can determine in situ the chemical composition of atherosclerotic lesions objectively and accurately. Raman spectroscopy is a powerful technique, capable of providing detailed, quantitative information about the chemical composition of arterial wall non-destructively. Such an instrument would be useful to clinicians and researchers in many applications, such as predicting plaque rupture and selecting proper therapeutic interventions. In this chapter, a review is given of the basic principles and potential applications of Raman spectroscopy.

Keywords

Raman Spectrum Raman Spectroscopy Calcify Plaque Scattered Photon Calcium Salt 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Small DM . George Lyman Duff memorial lecture. Progression and regression of atherosclerotic lesions. Insights from lipid physical biochemistry. Arteriosclerosis 1988;8:103–29. PubMedCrossRefGoogle Scholar
  2. 2.
    Steinberg D, Witztum JL. Lipoproteins and atherogenesis. JAMA 1990;264:3047–52.PubMedCrossRefGoogle Scholar
  3. 3.
    Stary HC. Composition and classification of human atherosclerosis. Virchows Archiv A Pathol Anat 1992;421:277–90.CrossRefGoogle Scholar
  4. 4.
    Loree HM, Tobias BJ, Gibson LJ, Kamm RD, Small DM, Lee RT. Mechanical properties of model atherosclerotic lesion lipid pools. Arterioscler Thromb 1994;14:230–4.PubMedCrossRefGoogle Scholar
  5. 5.
    Libby P. Molecular bases of the acute coronary syndromes. Circulation 1995;91:2844–50.PubMedGoogle Scholar
  6. 6.
    Manoharan R, Baraga JJ, Rava RP, Dasari RR, Fitzmaurice M, Feld MS. Biochemical analysis and mapping of atherosclerotic human artery using FT-IR microspectroscopy. Atherosclerosis 1993;103:181–93.PubMedCrossRefGoogle Scholar
  7. 7.
    Manoharan R, Baraga JJ, Feld MS, Rava RP. Quantitative histochemical analysis of human artery using Raman spectroscopy. J Photochem Photobiol B 1992;16:211–33.PubMedCrossRefGoogle Scholar
  8. 8.
    Baraga JJ, Feld MS, Rava RP. Rapid near-infrared Raman spectroscopy of human tissue with a spectrograph and a CCD detector. Appl Spectrosc 1992;46:187–90.CrossRefGoogle Scholar
  9. 9.
    Baraga JJ, Feld MS, Rava RP. In situ optical histochemistry of human artery using near infrared Fourier transform Raman spectroscopy. Proc Natl Acad Sci USA 1992;89:3473–7.PubMedCrossRefGoogle Scholar
  10. 10.
    Brennan III JFB, Wang Y, Dasari RR, Feld MS. Near-infrared Raman spectrometer systems for human tissue studies. Applied Spec 1997:201–8.Google Scholar
  11. 11.
    Kramer JR, Brennan III JF, Römer TJ, Wang Y, Dasari RR, Feld MS. Spectral diagnosis of human coronary artery: A clinical system for real time analysis. Proc. BIOS/SPIE 1998(23051):376–82.Google Scholar
  12. 12.
    Brennan III JF, Römer TJ, Tercyak AM et al. In situ histochemical analysis of human coronary artery by Raman spectroscopy compared with biochemical assay. Proc. BIOS/SPIE 1995(2388): 105–9.CrossRefGoogle Scholar
  13. 13.
    Brennan III JF, Römer TJ, Lees RS, Tercyak AM, Kramer JR Jr., Feld MS. Determination of human coronary artery composition by Raman spectroscopy. Circulation 1997:In press.Google Scholar
  14. 14.
    Römer TJ, Brennan III JF, Fitzmaurice M et al. Histopathology of human coronary atherosclerosis by quantifying its chemical composition with Raman spectroscopy. Circulation 1997:In press. Google Scholar
  15. 15.
    Carey PR. Biochemical applications of Raman and resonance Raman spectroscopy. New York: Academic press, 1982.Google Scholar
  16. 16.
    Tu AT. Raman spectroscopy in biology. New York: John Wiley and Sons, 1982.Google Scholar
  17. 17.
    Fehrmann A, Franz M, Hoffmann A, Rudzik L, Wust E, Dairy product analysis: identification of microorganisms by mid-infrared spectroscopy and determination of constituents by Raman spectroscopy. J AOAC Int 1995;78:1537–42.PubMedGoogle Scholar
  18. 18.
    Nave SE, O’Rourke PE, Toole WR. Sampling probes enhance remote chemical analysis. Laser Focus World 1995;12:83–8.Google Scholar
  19. 19.
    Yaroslavsky IV, Yaroslavsky AN, Otto C et al. Combined elastic and Raman light scattering of human eye lenses. Exp Eye Res 1994;59:393–9.PubMedCrossRefGoogle Scholar
  20. 20.
    Duindam HJ, Vrensen GF, Otto C, Puppels GJ, Greve J. New approach to assess the cholesterol distribution in the eye lens: confocal Raman microspectroscopy and filipin cytochemistry. J Lipid Res 1995;36:1139–46.PubMedGoogle Scholar
  21. 21.
    Thomas GJ Jr., Agard DA. Quantitative analysis of nucleic acids, proteins, and viruses by Raman band deconvolution. Biophys J 1984;46:763–8.PubMedCrossRefGoogle Scholar
  22. 22.
    van der Veen MH, ten Bosch JJ. The influence of mineral loss on the auto- fluorescent behaviour of in vitro demineralised dentine. Caries Res 1996;30:93–9.PubMedCrossRefGoogle Scholar
  23. 23.
    Tsuda H, Ruben J, Arends J. Raman spectra of human dentin mineral. Eur J Oral Sci 1996;104:123–31.PubMedCrossRefGoogle Scholar
  24. 24.
    Puppels GJ, de Mul FF, Otto C et al. Studying single living cells and chromosomes by confocal Raman microspectroscopy. Nature 1990;347:301–3.PubMedCrossRefGoogle Scholar
  25. 25.
    Kramer JR, Brennan III JF, Römer TJ, Wang Y, Dasari RR, Feld MS. Spectral diagnosis of human coronary artery: A clinical system for real time analysis. Proc. BIOS/SPIE 1998(23051):376–82.Google Scholar
  26. 26.
    Egeberg KD, Springer BA, Martinis SA, Sligar SG, Morikis D, Champion PM. Alteration of sperm whale myoglobin heme axial ligation by site-directed mutagenesis. Biochemistry 1990;29:9783–91.PubMedCrossRefGoogle Scholar
  27. 27.
    Peticolas WL. Raman spectroscopy of DNA and proteins. Methods Enzymol 1995;246:389–416.PubMedCrossRefGoogle Scholar
  28. 28.
    Lewis IR, Griffiths PR. Raman spectrometry with fiber-optic sampling. Applied Spec 1996;50:12A–30A.CrossRefGoogle Scholar
  29. 29.
    Loudon.The quantum theory of fight. (2nd ed.) Oxford: Oxford Science Pub., 1991. Google Scholar
  30. 30.
    Marcuse. Principles of quantum electronics. New York: Academic Press, 1980. Google Scholar
  31. 31.
    Yariv A. Quantum electronics. (3rd ed.) New York: John Wiley & Sons, 1975. Google Scholar
  32. 32.
    Chakravarti RN. Fifty years of Raman effect: 1928–1978. J Inst Chem (India) 1978.Google Scholar
  33. 33.
    Raman CV. A new radiation. Indian J Phys 1928;2:387–98.Google Scholar
  34. 34.
    Raman CV, Krishnan KS. A new type of secondary radiation. Nature 1928; 121:501–2.CrossRefGoogle Scholar
  35. 35.
    Raman CV. A change of wave-length in light scattering. Nature 1928; 121:618.CrossRefGoogle Scholar
  36. 36.
    Raman CV. The molecular scattering of light. Nobel Lecture. Stockholm: Imprimerie Royale, P.A. Norstedt, 1930.Google Scholar
  37. 37.
    Brennan III JF. Near infrared Raman spectroscopy for human artery histochemistry and histopathology. Cambridge: Massachusetts Institute of Technology, 1995.Google Scholar
  38. 38.
    Römer TJ, Brennan III JF, Bakker Schut TC et al. How deeply can near-infrared Raman spectroscopy detect cholesterol deposits in coronary arteries? Manuscript in preparation 199Google Scholar
  39. 39.
    Tracy RE, Kissling GE. Age and fibroplasia as preconditions for atheronecrosis in human coronary arteries. Arch Pathol Lab Med 1987;111:957–63.PubMedGoogle Scholar
  40. 40.
    Peters RJG, Kok WEM, Havenith MG, Rijsterborgh H, van der Wal AC, Visser CA. Histopathologic validation of intracoronary ultrasound imaging. J Am Soc Echocardiography 1994;7:230–41. Google Scholar
  41. 41.
    Mintz GS, Popma JJ, Pichard AD et al. Patterns of calcification in coronary artery disease. A statistical analysis of intravascular ultrasound and coronary angiography in 1155 lesions. Circulation 1995;91:1959–65. PubMedGoogle Scholar
  42. 42.
    Nissen SE, Gurley JC, Booth DC, De Maria AN. Intravascular ultrasound of the coronary arteries: current applications and future directions. Am J Cardiol 1992;69:18H–29H.PubMedCrossRefGoogle Scholar
  43. 43.
    Nissen SE, De Franco AC, Tuzco EM, Molitherno DJ. Coronary intravascular ultrasound: diagnostic and interventional applications. Coronary artery disease 1995;6:355–67.PubMedCrossRefGoogle Scholar
  44. 44.
    Benkeser PJ, Churchwell AL, Lee C, Abouelnasr D. Resolution limitations in intravascular ultrasound imaging. J Am Soc Echocardiogr 1993;6:158–65.PubMedGoogle Scholar
  45. 45.
    Groot PH, van Vlijmen BJ, Benson GM et al. Quantitative assessment of aortic atherosclerosis in APOE*3 Leiden transgenic mice and its relationship to serum cholesterol exposure. Arterioscler Thromb Vasc Biol 1996;16:926–33. CrossRefGoogle Scholar
  46. 46.
    Jukema JW, Zwinderman AH, van Boven AJ et al. Evidence for a synergistic effect of calcium channel blockers with lipid-lowering therapy in retarding progression of coronary atherosclerosis in symptomatic patients with normal to moderately raised cholesterol levels. The REGRESS Study Group. Arterioscler Thromb Vasc Biol 1996;16:425–30. PubMedCrossRefGoogle Scholar

Copyright information

© Kluwer Academic Publishers 1997

Authors and Affiliations

  • Tjeerd J. Römer
  • James F. BrennanIII

There are no affiliations available

Personalised recommendations