The Pathogenesis of Cancer Metastasis: Relevance to Biotherapy

  • Robert Radinsky
  • Sharon L. Aukerman
  • Isaiah J. Fidler

Abstract

Metastasis — the spread of malignant tumor cells from a primary neoplasm to distant parts of the body where they multiply to form new growths — is a major cause of death from cancer. The treatment of cancer poses a major problem to clinical oncologists, because by the time many cancers are diagnosed, metastasis may already have occurred, and the presence of multiple metastases makes complete eradication by surgery, radiation, drugs, or biotherapy nearly impossible (Table 1). Metastases can be located in different organs and in different locations within the same organ. These aspects significantly influence the response of tumor cells to therapy and the efficiency of anticancer drugs, which must be delivered to tumor foci in amounts sufficient to destroy cells without leading to undesirable side effects. Similarly, immune effector cells of current biotherapeutic regimens may have difficulty reaching or localizing in some metastatic sites.

Keywords

Epidermal Growth Factor Receptor Nude Mouse Cancer Metastasis Natl Cancer Inst Metastatic Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • Robert Radinsky
    • 1
  • Sharon L. Aukerman
    • 1
  • Isaiah J. Fidler
    • 1
  1. 1.Department of Cell BiologyThe University of Texas M. D. Anderson Cancer CenterHoustonUSA

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