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Role of Lipid Peroxide in the Neurodegenerative Disorders

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Lipid Hydroperoxide-Derived Modification of Biomolecules

Part of the book series: Subcellular Biochemistry ((SCBI,volume 77))

Abstract

Nervous system controls all the organs in the living like a symphony. In this chapter, the mechanism of neuronal death in aged is discussed in relation to oxidative stress. Polyunsaturated fatty acid (PUFA) is known to be rich in the membranous component of the neurons and plays an important role in maintaining the neuronal functions. Recent reports revealed that oxidation of omega-3 and omega-6 PUFAs, such as docosahexaenoic acid (DHA) and arachidonic acid (ARA), are potent antioxidant but simultaneously, their oxidation products are potentially toxic. In this chapter, the existence of early oxidation products of PUFA is examined in the samples from neurodegenerative disorders and the cellular model. Accumulation of proteins with abnormal conformation is suggested to induce neuronal death by disturbance of proteolysis and mitochondrial function. The role of lipid peroxide and lipid-derived aldehyde adduct proteins is discussed in relation to brain ageing and age-related neurodegeneration.

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Acknowledgement

This work was supported by the Research Funding for Longevity Sciences (23–2) from National Center for Geriatrics and Gerontology (NCGG) and Grant-in-Aid for Scientific Research (A) (Grant Number 24248024) from JSPS (W. M.).

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Authors and Affiliations

  1. Department of Cognitive Brain Science, National Institute for Geriatrics and Gerontology, 35 Morioka, Obu, Aichi, 474-8511, Japan

    Wakako Maruyama & Masayo Shaomoto-Nagai

  2. School of Human Science and Environment, University of Hyogo, Himeji, 670-0092, Japan

    Yoji Kato

  3. Department of Pharmacognosy, Faculty of Pharmacy, Meijyo University, 150 Yagoto-yama, Tenpaku, Nagoya, Aichi, 468-8503, Japan

    Shinsuke Hisaka

  4. Department of Nutritional Science, Aichi Gakuin University, Nisshin, 470-0195, Aichi, Japan

    Toshihiko Osawa & Makoto Naoi

Authors
  1. Wakako Maruyama
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  2. Masayo Shaomoto-Nagai
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  3. Yoji Kato
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  4. Shinsuke Hisaka
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  5. Toshihiko Osawa
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  6. Makoto Naoi
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Corresponding author

Correspondence to Wakako Maruyama .

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Editors and Affiliations

  1. School of Human Science & Environment, University of Hyogo, Himeji, Hyogo, Japan

    Yoji Kato

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Maruyama, W., Shaomoto-Nagai, M., Kato, Y., Hisaka, S., Osawa, T., Naoi, M. (2014). Role of Lipid Peroxide in the Neurodegenerative Disorders. In: Kato, Y. (eds) Lipid Hydroperoxide-Derived Modification of Biomolecules. Subcellular Biochemistry, vol 77. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7920-4_11

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