Quantitative Analysis of Disease Biomarkers Using Surface-Enhanced Raman Scattering Spectroscopy

  • Jaebum ChooEmail author
  • Hyangah Chon
Part of the Challenges and Advances in Computational Chemistry and Physics book series (COCH, volume 14)


In this chapter, we describe the SERS-based immunoassay technique for the highly sensitive detection of various disease biomarkers. The fundamentals of the technique are briefly presented, and three different SERS assay platforms and their biomedical applications are described. The novel SERS-based assay technique is expected to be a powerful clinical tool for early disease diagnosis.


surface-enhanced Raman scattering (SERS) immunoassay biomarker early diagnosis microfluidics 



The National Research Foundation of Korea supported this work (grant numbers R11-2008-0061852 and K20904000004-12A0500-00410). This research was also supported by the Nano Material Technology Development Program through the National Research Foundation of Korea funded by the Ministry of Education, Science, and Technology (grant number 2012035286) and by the Agency for Defense Development through Chemical and Biological Defense Research Center.


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Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  1. 1.Department of Bionano Engineering and Center for Integrated Human Sensing SystemHanyang UniversityAnsanKorea
  2. 2.Department of Bionano EngineeringHanyang UniversityAnsanKorea

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