Abstract
Assisted by surface receptors of susceptible cells, HIV can successfully get access to cells, including the first receptors and the second receptors. Firstly, envelope glycoprotein gp120 of HIV-1 binds to the first receptors, followed by its binding to the second receptors. Its structural changes cause its detachment from gp41, resulting in fusion of HIV and host cellular membrane and its successful access to host cells. Within 24–48 h after its access, HIV reaches the local lymph nodes. At d 5, HIV components can be detected in the peripheral blood. The attack of HIV causes viremia, leading to acute infection.
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© 2014 Springer Science+Business Media Dordrecht and People’s Medical Publishing House
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Li, H. (2014). Pathogenetic and Pathological Mechanism. In: Li, H. (eds) Radiology of HIV/AIDS. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7823-8_5
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DOI: https://doi.org/10.1007/978-94-007-7823-8_5
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