HIV/AIDS Related Cardiac Diseases

  • Hongjun Li


Cardiovascular diseases occur in patients with AIDS of its advanced stage. The cardiovascular complications include dilated cardiomyopathy, pericardial effusion, endocarditis, cardiac dysfunction, pulmonary hypertension and arrhythmia. Left ventricular dysfunction is more common in the advanced stage. Since the year of 1981, there has been increasingly clinical and autopsy reports about AIDS complicated by cardiopathy, with the most frequently reported cases of pericarditis or pericardial effusion and occasionally accompanying cardiac tamponade. In adults and children AIDS patients, about 20–40 % is found to have pericarditis. According to the autopsy reports, the incidence of pericardiac lesions is 3–37 %, while its incidence by echocardiography is 30–38 %. HIV/AIDS related cardiopathy is a kind of non-inflammatory heart disease that is related to dysmetabolism. Myocardium is the basic dynamic tissue for the contraction and relaxation of the heart, and it is particularly sensitive to infections, hypoxia, drugs and toxins. Among AIDS patients, dilated and hypertrophic myocardial diseases are more common. By myocardium tissue culture, HIV can be found, although some scholars believed that HIV attacks hemoglobin instead of myocardial tissue. In 5 % cases of myocarditis in AIDS patients by autopsy, only 20 % is pathologically confirmed as having dilated myocardiopathy. By electrocardiography, 30–45 % cases of AIDS complicated by cardiopathy show abnormalities.


Pulmonary Hypertension Dilate Cardiomyopathy Pericardial Effusion Cardiac Tamponade Left Ventricular Systolic Dysfunction 
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Extended Reading

  1. 1.
    Barbaro G. Cardiovascular manifestations of HIV infection [J]. Circulation. 2002;106(11):1420–5.PubMedCrossRefGoogle Scholar
  2. 2.
    Barbaro G, Barbarini G, Pellicelli AM. HIV associated coronary arteritis in a patient with fatal myocardial infarction [J]. N Engl J Med. 2001;344(23):1799–800.PubMedCrossRefGoogle Scholar
  3. 3.
    Barbaro G, Fisher SD, Lipshultz SE. Pathogenesis of HIV associated cardiovascular complications [J]. Lancet Infect Dis. 2001;1(2):115–24.PubMedCrossRefGoogle Scholar
  4. 4.
    Braithwaite RS, Concato J, Chang CC, et al. A framework for tailoring clinical guidelines to comorbidity at the point of care [J]. Arch Intern Med. 2007;167(21):2361–5.PubMedCentralPubMedCrossRefGoogle Scholar
  5. 5.
    Calabrese LH. Infection with the human immunodeficiency virus type 1 and vascular inflammatory disease [J]. Clin Exp Rheumatol. 2004;22(6 Suppl 36):S87–93.PubMedGoogle Scholar
  6. 6.
    Chaves AA, Mihm MJ, Schanbacher BI. Cardiomyopathy in a murine model of AIDS: evidence of reactive nitrogen species and corroboration in HIV/AIDS cardiac tissues [J]. Cardiovasc Res. 2003;60(1):108–18.PubMedCrossRefGoogle Scholar
  7. 7.
    Cotter BR. Epidemiology of HIV cardiac disease [J]. Prog Cardiovasc Dis. 2003;45(4):319–26.PubMedCrossRefGoogle Scholar
  8. 8.
    Herskowitz A, Vlahov D, Willoughby S, et al. Prevalence and incidence of left ventricular dysfunction in patients with human immunodeficiency virus infection [J]. Am J Cardiol. 1993;71(11):955–8.PubMedCrossRefGoogle Scholar
  9. 9.
    Herskowitz A, Willoughby SB, Baughman KL. Cardiomyopathy associated with anti-retroviral therapy in patients with human immunodeficiency virus infections: a report of six cares. Ann Intern Med. 1992;116:311.PubMedCrossRefGoogle Scholar
  10. 10.
    Maserli R, Parsi A. Rapidly reversible cardiomyopathy in an AIDS patients. AIDS. 1991;5:1145.CrossRefGoogle Scholar
  11. 11.
    Miller RF, Howling SJ, Reid AJ, et al. Pleural effusions in patient s with AIDS [J]. Sex Transm Infect. 2000;76(2):122–5.PubMedCrossRefGoogle Scholar
  12. 12.
    Nzuobontane D, Blackett KN, Kuaban C. Cardiac involvement in HIV infected people in Yaounde Cameroon [J]. Postgrad Med J. 2002;78(925):678–81.PubMedCrossRefGoogle Scholar
  13. 13.
    Pellicelli A, Barbaro G, Palmieri F, et al. Primary pulmonary hypertension in HIV disease: a systematic review [J]. Angiology. 2001;52(1):31–41.PubMedGoogle Scholar
  14. 14.
    SilvaCardoso J, Moura B, Martins L, et al. Pericardial involvement in human immunodeficiency virus infection [J]. Chest. 1999;115(2):418–22.CrossRefGoogle Scholar
  15. 15.
    Wang XF. Echocardiography [M]. 3rd ed. Beijing: People’s Medical Publishing House, PMPH; 1999. p. 283–553.Google Scholar

Copyright information

© Springer Science+Business Media Dordrecht and People’s Medical Publishing House 2014

Authors and Affiliations

  • Hongjun Li
    • 1
  1. 1.Radiology Department Beijing You’an HospitalCapital Medical UniversityBeijingPeople’s Republic of China

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