HIV/AIDS Related Myeleterosis and Peripheral Neuropathy

  • Hongjun Li


Up to now, reports about HIV/AIDS related myelopathy remain rare in China. McArthur collected 186 cases of HIV/AIDS complicated by brain and peripheral nerve lesions in the year of 1987 [11]. Only 13 cases had HIV/AIDS related myelopathy, accounting for 7 %. Levy et al. [8] reported the occurrence of HIV/AIDS related myelopathy is 2–22 % based on literature analysis. In another group of 150 patients with AIDS, 42 had HIV/AIDS related myelopathy, in which 24 % with spinal degeneration, 38 % with viral infection, 5 % with toxoplasmosis, 2 % with myelitis and the other 31 % with no pathological diagnosis [2]. Surprisingly, myelopathy is commonly found by autopsy. Peter and his fellow researchers [14] found 50 % of the total 178 patients with AIDS have myelopathy, with 29 % spinal degeneration, 5 % HIV myelitis, 8 % viral infection, 7 % other infections and 2 % lymphoma. Budka [3] retrospectively reviewed autopsies of 475 death cases from AIDS in 1997 and found that 22.5 % had spinal degeneration, 6 % myelitis, 58 % viral infection and 4.1 % fungal, bacterial and protozoal infections as well as 2.3 % lymphoma. Since the year of 1997, knowledge about the clinical treatment for HIV/AIDS complicated by myelopathy has been greatly improved.


Spinal Cord Varicella Zoster Virus Epidural Abscess Toxoplasma Infection Abscess Wall 
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Extended Reading

  1. 1.
    Anneken K, Fischera M, Evers S, et al. Recurrent vacuolar myelopathy in HIV infection. J Infect. 2006;52(6):e181–3.PubMedCrossRefGoogle Scholar
  2. 2.
    Bredesen DE, Levy RM, Rosenblum ML. The neurology of human immunodeficiency virus infection. Q J Med. 1988;68(25):665–77.PubMedGoogle Scholar
  3. 3.
    Budka H. Neuropathology of myelitis, myelopathy, and spinal infections in AIDS. Neuroimaging Clin N Am. 1997;7(3):639–50.PubMedGoogle Scholar
  4. 4.
    Claeke TR, Barrow G, Glibert DT, et al. A possible case of spinal tuberculosis in a HIV-positive male. West Indian Med J. 2010;59(4):453–4.Google Scholar
  5. 5.
    England JD, Gronseth GS, Franklin G, et al. Practice parameter: the evaluation of distal symmetric polyneuropathy: the role of laboratory and genetic testing (an evidence-based review): report of the American Academy of Neurology, the American Association of Neuromuscular and Electrodiagnostic Medicine, and the American Academy of Physical Medicine and Rehabilitation. PM&R. 2009;1:5–13.CrossRefGoogle Scholar
  6. 6.
    Fuller GN. Cytomegalovirus and the peripheral nervous system in AIDS. J Acquir Immune Defic Syndr. 1992;5(Suppl):33–6.Google Scholar
  7. 7.
    Husstedt IW, Evers S, Reichelt D, et al. Screening for HIV-associated distal-symmetric polyneuropathy in CDC-classification stages 1, 2 and 3. Acta Neurol Scand. 2000;101:183–7.PubMedCrossRefGoogle Scholar
  8. 8.
    Levy RM, Bredesen DE, Rosenblum ML. Neurological manifestations of the acquired immunodeficiency syndrome(AIDS):experience at UCSF and review of the literature. J Neurosurg. 1985;62(4):475–95.PubMedCrossRefGoogle Scholar
  9. 9.
    Marra CM, Boutin P, Collier AC. Screening for distal sensory peripheral neuropathy in HIV-infected persons in research and clinical settings. Neurology. 1998;51:1678–81.PubMedCrossRefGoogle Scholar
  10. 10.
    Maschke M, Kastrup O, Esser S. Incidence and prevalence of neurological disorders associated with HIV since the introduction of highly active antiretroviral therapy (HAART). J Neurol Neurosurg Psychiatry. 2000;69:376–80.PubMedCrossRefGoogle Scholar
  11. 11.
    McArthur JCN, Hoover DR, Bacellar H, Miller EN, et al. Dementia in AIDS patients : incidence and risk factors. Multicenter AIDS Cohort Study. Neurology. 1993;43(11):2245–52.PubMedCrossRefGoogle Scholar
  12. 12.
    Molina-Olier O, Tunon-Pitalua M, Alcala-Cerra G, et al. Spinal cord compression due to intraspinal gumma in one patient. Clinical case. Acta Ortop Mex. 2012;26(3):197–201.PubMedGoogle Scholar
  13. 13.
    Nakamura M, Fujishima S, Hori S, et al. An adult case of cervico-mediastinal tuberculous lymphadenitis. Nihon Kokyuki Gakkai Zasshi. 2000;38(3):223–8.PubMedGoogle Scholar
  14. 14.
    Peter SA, Brignol YF, Razavi MH, et al. Diffuse hyperpigmentation associated with acquired immunodeficiency syndrome. J Natl Med Assoc. 1992;84(11):977–9.PubMedGoogle Scholar
  15. 15.
    Petito CK, Navia BA, Cho ES, et al. Vacuolar myelopathy pathologically resembling subacute combined degeneration in patients with the acquired immunodeficiency syndrome. N Engl J Med. 1985;312(14):874–9.PubMedCrossRefGoogle Scholar
  16. 16.
    Wulff EA, Wang AK, Simpson DM. HIV-associated peripheral neuropathy epidemiology. Pathophysiology and treatment. Drugs. 2000;59(6):1251–60.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht and People’s Medical Publishing House 2014

Authors and Affiliations

  • Hongjun Li
    • 1
  1. 1.Radiology Department Beijing You’an HospitalCapital Medical UniversityBeijingPeople’s Republic of China

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