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Gamete and Embryo-fetal Origins of Adult Diseases pp 109–136Cite as

Gamete/Embryo-Fetal Origins of Tumours

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Abstract

Epidemiological and animal studies indicate that carcinogenesis may start as early as the prenatal period. Modifying the prenatal environment may alter genes through the epigenetic route, and, these alterations may be inherited by the offspring. Epigenetic factors like nutritional factors, endocrine disruptors, infection and lifestyle may affect tumour development, or, target cell differentiation to increase susceptibility to cancer. In this chapter, we discuss the evidence related to embryo-fetal origins of tumours.

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Authors and Affiliations

  1. The Key Laboratory of Reproductive Genetics, Zhejiang University, Ministry of Education, Hangzhou, People’s Republic of China

    Dan Zhang, He-Feng Huang, Feng Zhang, Run-Ju Zhang, Yang Song & Jing-Yi Li

  2. Department of Reproductive Endocrinology, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, People’s Republic of China

    Dan Zhang, He-Feng Huang, Run-Ju Zhang, Yang Song & Jing-Yi Li

  3. Department of Surgery, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, People’s Republic of China

    Feng Zhang

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    He-Feng Huang

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    Jian-Zhong Sheng

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Zhang, D., Huang, HF., Zhang, F., Zhang, RJ., Song, Y., Li, JY. (2014). Gamete/Embryo-Fetal Origins of Tumours. In: Huang, HF., Sheng, JZ. (eds) Gamete and Embryo-fetal Origins of Adult Diseases. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7772-9_6

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