Abstract
Human embryo development is a complex process. The life of an embryo begins when a male’s spermatozoa makes contact with a woman’s egg. A zygote cell, the very first representation of the fetus, is the result of this fertilization process. Contained within this one cell is the DNA of both the male and female, as well as the blueprint from which the fetus will develop. This chapter reviews some of the basic physiology of embryonic development.
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References
Arushi, Khurana I. Human embryology. 1st ed. New Delhi: CBS Publisher & Distributors Pvt Ltd.; 2010.
Gulyas BJ. A reexamination of cleavage patterns in eutherian mammalian eggs: rotation of blastomere pairs during second cleavage in the rabbit. J Exp Zool. 1975;193:235–48.
Gardner RL. The early blastocyst is bilaterally symmetrical and its axis of symmetry is aligned with the animal-vegetal axis of the zygote in the mouse. Development. 1997;124:289–301.
Garner W, McLaren A. Cell distribution in chimaeric mouse embryos before implantation. J Embryol Exp Morphol. 1974;32:495–503.
Beddington RS, Robertson EJ. Axis development and early asymmetry in mammals. Cell. 1999;96:195–209.
Gross PR, Cousineau GH. Synthesis of spindle-associated proteins in early cleavage. J Cell Biol. 1963;19:260–5.
Crosby IM, Gandolfi F, Moor RM. Control of protein synthesis during early cleavage of sheep embryos. J Reprod Fertil. 1988;82:769–75.
Lee S, Gilula NB, Warner AE. Gap junctional communication and compaction during preimplantation stages of mouse development. Cell. 1987;51:851–60.
Levy JB, Johnson MH, Goodall H, et al. The timing of compaction: control of a major developmental transition in mouse early embryogenesis. J Embryol Exp Morphol. 1986;95:213–37.
Handyside AH. Distribution of antibody- and lectin-binding sites on dissociated blastomeres from mouse morulae: evidence for polarization at compaction. J Embryol Exp Morphol. 1980;60:99–116.
Pratt HP, Ziomek CA, Reeve WJ, et al. Compaction of the mouse embryo: an analysis of its components. J Embryol Exp Morphol. 1982;70:113–32.
Reeve WJ, Ziomek CA. Distribution of microvilli on dissociated blastomeres from mouse embryos: evidence for surface polarization at compaction. J Embryol Exp Morphol. 1981;62:339–50.
Sutherland AE, Speed TP, Calarco PG. Inner cell allocation in the mouse morula: the role of oriented division during fourth cleavage. Dev Biol. 1990;137:13–25.
Carlson BM. Foundations of embryology. 6th ed. New York: McGraw-Hill; 1996.
Barlow PW, Sherman MI. The biochemistry of differentiation of mouse trophoblast: studies on polyploidy. J Embryol Exp Morphol. 1972;27:447–65.
Johnson MH, McConnell JM. Lineage allocation and cell polarity during mouse embryogenesis. Semin Cell Dev Biol. 2004;15:583–97.
Marikawa Y, Alarcón VB. Establishment of trophectoderm and inner cell mass lineages in the mouse embryo. Mol Reprod Dev. 2009;76:1019–32.
Müntener M, Hsu YC. Development of trophoblast and placenta of the mouse. A reinvestigation with regard to the in vitro culture of mouse trophoblast and placenta. Acta Anat (Basel). 1977;98:241–52.
Fleming TP. A quantitative analysis of cell allocation to trophectoderm and inner cell mass in the mouse blastocyst. Dev Biol. 1987;119:520–31.
Pijnenborg R, Robertson WB, Brosens I, et al. Review article: trophoblast invasion and the establishment of haemochorial placentation in man and laboratory animals. Placenta. 1981;2:71–91.
Ziomek CA, Johnson MH. The roles of phenotype and position in guiding the fate of 16-cell mouse blastomeres. Dev Biol. 1982;91:440–7.
Yamanaka Y, Ralston A, Stephenson RO, et al. Cell and molecular regulation of the mouse blastocyst. Dev Dyn. 2006;235:2301–14.
Goto T, Monk M. Regulation of X-chromosome inactivation in development in mice and humans. Microbiol Mol Biol Rev. 1998;62:362–78.
McGrath J, Solter D. Completion of mouse embryogenesis requires both the maternal and paternal genomes. Cell. 1984;37:179–83.
Garbutt CL, Johnson MH, George MA. When and how does cell division order influence cell allocation to the inner cell mass of the mouse blastocyst? Development. 1987;100:325–32.
Gurdon JB, Byrne JA. The first half-century of nuclear transplantation. Proc Natl Acad Sci U S A. 2003;100:8048–52.
Smith JM. The theory of evolution. Cambridge: Cambridge University Press; 1993.
Gibert SF. Developmental biology. Sunderland: Sinauer Associates, Inc.; 2000.
Williams GC. Adaptation and natural selection. Princeton: Princeton University Press; 1996.
Gurdon JB, Hopwood N. The introduction of Xenopus laevis into developmental biology: of empire, pregnancy testing and ribosomal genes. Int J Dev Biol. 2000;44:43–50.
Sander K, Faessler PE. Introducing the Spemann-Mangold organizer: experiments and insights that generated a key concept in developmental biology insights that generated a key concept in developmental biology. Int J Dev Biol. 2001;45:1–11.
Wolpert L, Jessell T, Lawrence P, et al. Principles of development. 3rd ed. Oxford: Oxford University Press; 2007.
Davidson EH. Gene activity in early development. 2nd ed. New York: Academic; 1976. p. 452.
Gandolfi TA, Gandolfi F. The maternal legacy to the embryo: cytoplasmic components and their effects on early development. Theriogenology. 2001;55:1255–76.
Memili E, First NL. Zygotic and embryonic gene expression in cow: a review of timing and mechanisms of early gene expression as compared with other species. Zygote. 2000;8:87–96.
Biggers JD, Borland RM. Physiological aspects of growth and development of the preimplantation mammalian embryo. Annu Rev Physiol. 1976;38:95–119.
Dworkin MB, Dworkin-Rastl E. Functions of maternal mRNA in early development. Mol Reprod Dev. 1990;26:261–97.
Wang Q, Chung YG, deVries WN, Struwe M, Latham KE. Role of protein synthesis in the development of a transcriptionally permissive state in one-cell stage mouse embryos. Biol Reprod. 2001;65:748–54.
Bao S, Obata Y, Carroll J, et al. Epigenetic modifications necessary for normal development are established during oocyte growth in mice. Biol Reprod. 2000;62:616–21.
Allegrucci C, Thurston A, Lucas E, et al. Epigenetics and the germline. Reproduction. 2005;129:137–49.
Tada M, Tada T, Lefebvre L, et al. Embryonic germ cells induce epigenetic reprogramming of somatic nucleus in hybrid cells. EMBO J. 1997;16:6510–20.
Simon I, Tenzen T, Reubinoff BE, et al. Asynchronous replication of imprinted genes is established in the gametes and maintained during development. Nature. 1999;401:929–32.
Hajkova P, Erhardt S, Lane N, et al. Epigenetic reprogramming in mouse primordial germ cells. Mech Dev. 2002;117:15–23.
Obata Y, Kono T. Maternal primary imprinting is established at a specific time for each gene throughout oocyte growth. J Biol Chem. 2002;277:5285–9.
Okano M, Bell DW, Haber DA, et al. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell. 1999;99:247–57.
DiZio SM, Tasca RJ. Sodium-dependent amino acid transport in preimplantation mouse embryos: III. Na+-K+-ATPase-linked mechanism in blastocysts. Dev Biol. 1977;59:198–205.
Johansson M, Jansson T, Powell TL. Na(+)-K(+)-ATPase is distributed to microvillous and basal membrane of the syncytiotrophoblast in human placenta. Am J Physiol Regul Integr Comp Physiol. 2000;279:R287–94.
Vu TK, Liu RW, Haaksma CJ, Tomasek JJ, et al. Identification and cloning of the membrane-associated serine protease, hepsin, from mouse preimplantation embryos. J Biol Chem. 1997;272:31315–20.
Perona RM, Wassarman PM. Mouse blastocysts hatch in vitro by using a trypsin-like proteinase associated with cells of mural trophectoderm. Dev Biol. 1986;114:42–52.
Das SK, Wang XN, Paria BC, et al. Heparin-binding EGF-like growth factor gene is induced in the mouse uterus temporally by the blastocyst solely at the site of its apposition: a possible ligand for interaction with blastocyst EGF-receptor in implantation. Development. 1994;120:1071–83.
Aplin JD, Seif MW, Graham RA, et al. The endometrial cell surface and implantation. Expression of the polymorphic mucin MUC-1 and adhesion molecules during the endometrial cycle. Ann N Y Acad Sci. 1994;734:103–21.
Sidhu SS, Kimber SJ. Hormonal control of H-type alpha(1–2)fucosyltransferase messenger ribonucleic acid in the mouse uterus. Biol Reprod. 1999;60(1):147–57.
Gilbert SF. The epidermis and the origin of cutaneous structures. In: Developmental biology. 6th ed. Sunderland: Sinauer Associates; 2000.
Gilbert SF. Comparative embryology. In: Developmental biology. 6th ed. Sunderland: Sinauer Associates; 2000.
Gilbert SF. Early mammalian development. In: Developmental biology. 6th ed. Sunderland: Sinauer Associates; 2000.
Hall BK. The neural crest as a fourth germ layer and vertebrates as quadroblastic not triploblastic. Evol Dev. 2000;2:3–5.
Moore KL. The developing human. 2nd ed. Philadelphia: Saunders; 1977.
Moore KL. The developing human: clinically oriented embryology. 4th ed. Philadelphia: Saunders; 1988.
Moore KL. Before we are born. Basic embryology and birth defects. Philadelphia: Saunders; 1983.
Usher R, Shephard M, Lind J. The blood volume of the newborn infant and placental transfusion. Acta Paediatr. 1963;52:497–512.
Jansson T, Powell TL. Human placental transport in altered fetal growth: does the placenta function as a nutrient sensor? A review. Placenta. 2006;27:S91.
Sipes SL, Weiner CP, Wenstrom KD, et al. The association between fetal karyotype and mean corpuscular volume. Am J Obstet Gynecol. 1991;165:1371–6.
Pearson HA. Recent advances in hematology. J Pediatr. 1966;69:466–79.
Weiner CP, Sipes SL, Wenstrom K. The effect of fetal age upon normal fetal laboratory values and venous pressure. Obstet Gynecol. 1992;79:713–18.
Fryer AA, Jones P, Strange R, et al. Plasma protein levels in normal human fetuses: 13 to 41 weeks’ gestation. Br J Obstet Gynaecol. 1993;100:850–5.
Foley ME, Isherwood DM, McNicol GP. Viscosity, hematocrit, fibrinogen and plasma proteins in maternal and cord blood. Br J Obstet Gynaecol. 1978;85:500–4.
Koldovsky O, Heringova A, Jirsova V, et al. Transport of glucose against a concentration gradient in everted sacs of jejunum and ileum of human fetuses. Gastroenterology. 1965;48:185–7.
Miller AJ. Deglutition. Physiol Rev. 1982;62:129–84.
Pritchard JA. Fetal swallowing and amniotic fluid volume. Obstet Gynecol. 1966;28:606–10.
Lebenthal E, Lee PC. Review article. Interactions of determinants of the ontogeny of the gastrointestinal tract: a unified concept. Pediatr Res. 1983;1:19–24.
Bashore RA, Smith F, Schenker S. Placental transfer and disposition of bilirubin in the pregnant monkey. Am J Obstet Gynecol. 1969;103:950–8.
Adam PAJ, Teramo K, Raiha N, et al. Human fetal insulin metabolism early in gestation: response to acute elevation of the fetal glucose concentration and placental transfer of human insulin-I-131. Diabetes. 1969;18:409–16.
Obenshain SS, Adam PAJ, King KC, et al. Human fetal insulin response to sustained maternal hyperglycemia. N Engl J Med. 1970;283:566–70.
Werlin SL. Exocrine pancreas. In: Polin RA, Fox WW, editors. Fetal and neonatal physiology. Philadelphia: Saunders; 1992. p. 1047.
Davis MM, Hodes ME, Munsick RA, et al. Pancreatic amylase expression in human pancreatic development. Hybridoma. 1986;5:137–45.
Saxén L, Sariola H. Early organogenesis of the kidney. Pediatr Nephrol. 1987;1:385–92.
Geelhoed JJ, Verburg BO, Nauta J, et al. Tracking and determinants of kidney size from fetal life until the age of 2 years: the Generation R Study. Am J Kidney. 2009;53(2):248–58.
Smith FG, Nakamura KT, Segar JL et al. In: Polin RA, Fox WW, editors. Fetal and neonatal physiology, vol 2, Chap. 114. Philadelphia: Saunders; 1992. p. 1187.
Wladimiroff JW, Campbell S. Fetal urine-production rates in normal and complicated pregnancy. Lancet. 1974;1:151–4.
Chard T, Hudson CN, Edwards CRW, et al. Release of oxytocin and vasopressin by the human foetus during labour. Nature. 1971;234:352–4.
Polin RA, Husain MK, James LS, et al. High vasopressin concentrations in human umbilical cord blood—lack of correlation with stress. J Perinat Med. 1977;5:114–19.
Ballabio M, Nicolini U, Jowett T, et al. Maturation of thyroid function in normal human foetuses. Clin Endocrinol. 1989;31:565–71.
Thorpe-Beeston JG, Nicolaides KH, Felton CV, et al. Maturation of the secretion of thyroid hormone and thyroid-stimulating hormone in the fetus. N Engl J Med. 1991;324:532–6.
Wenstrom KD, Weiner CP, Williamson RA, et al. Prenatal diagnosis of fetal hyperthyroidism using funipuncture. Obstet Gynecol. 1990;76:513–17.
Vulsma T, Gons MH, De Vijlder JJ. Maternal-fetal transfer of thyroxine in congenital hypothyroidism due to a total organification defect or thyroid agenesis. N Engl J Med. 1989;321:13–6.
Koff AK. Development of the vagina in the human fetus. Contrib Embryol. 1933;24:59–91.
Konishi I, Fujii S, Okamura H, et al. Development of interstitial cells and ovigerous cords in the human fetal ovary: an ultrastructural study. J Anat. 1986;148:121–35.
Bozzetti P, Ferrari MM, Marconi AM, et al. The relationship of maternal and fetal glucose concentrations in the human from midgestation until term. Metabolism. 1988;37:358–63.
Hauguel-de Mouzon S, Lepercq J, Catalano P. The known and unknown of leptin in pregnancy. Am J Obstet Gynecol. 2006;193(6):1537–45.
Grisaru-Granovsy S, Samueloff A, Elstein D. The role of leptin in fetal growth: a short review from conception to delivery. Eur J Obstet Gynecol Reprod Biol. 2008;136(2):146–50.
Kimura RE. Lipid metabolism in the fetal-placental unit. In: Cowett RM, editor. Principles of perinatal-neonatal metabolism. New York: Springer; 1991. p. 291.
Lemons JA. Fetal placental nitrogen metabolism. Semin Perinatol. 1979;3:177–90.
Morriss FH Jr, Boyd RDH, Manhendren D. Placental transport. In: Knobil E, Neill J, editors. The physiology of reproduction, vol II. New York: Raven; 1994. p. 813.
Fowden AL, Ward JW, Wooding FP, et al. Programming placental nutrient transport capacity. J Physiol. 2006;572(1):5–15.
Jansson T, Powell TL. IFPA 2005 Award in Placentology Lecture. Human placental transport in altered fetal growth: does the placenta function as a nutrient sensor? – a review. Placenta. 2006;27:S91–7.
Gitlin D, Kumate J, Morales C, et al. The turnover of amniotic fluid protein in the human conceptus. Am J Obstet Gynecol. 1972;113:632–45.
Abbas SK, Pickard DW, Illingworth D, et al. Measurement of PTH-rP protein in extracts of fetal parathyroid glands and placental membranes. J Endocrinol. 1990;124:319–25.
Hellman P, Ridefelt P, Juhlin C, et al. Parathyroid-like regulation of parathyroid hormone related protein release and cytoplasmic calcium in cytotrophoblast cells of human placenta. Arch Biochem Biophys. 1992;293:174–80.
Gilbert WM, Brace RA. Amniotic fluid volume and normal flows to and from the amniotic cavity. Semin Perinatol. 1993;17:150–7.
Brace RA, Wolf EJ. Normal amniotic fluid volume changes throughout pregnancy. Am Obstet Gynecol. 1989;161:382–8.
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Liu, AX., Liu, XM., Zhang, YL., Huang, HF., Xu, CM. (2014). Physiology of Embryonic Development. In: Huang, HF., Sheng, JZ. (eds) Gamete and Embryo-fetal Origins of Adult Diseases. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7772-9_2
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