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Flow of Red Blood Cells Suspensions Through Hyperbolic Microcontractions

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Visualization and Simulation of Complex Flows in Biomedical Engineering

Abstract

The present study uses a hyperbolic microchannel with a low aspect ratio (AR) to investigate how the red blood cells (RBCs) deform under conditions of both extensional and shear induced flows. The deformability is presented by the degree of the deformation index (DI) of the flowing RBCs throughout the microchannel at its centerline. A suitable image analysis technique is used for semi-automatic measurements of average DIs, velocity and strain rate of the RBCs travelling in the regions of interest. The results reveal a strong deformation of RBCs under both extensional and shear stress dominated flow conditions.

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Acknowledgments

The authors acknowledge the financial support provided by: International Doctoral Program in Engineering, from the Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT), 2007 Global COE Program “Global Nano-Biomedical Engineering Education and Research Network”, Japan. Grant-in-Aid for Science and Technology (PTDC/SAU-BEB/108728/2008, PTDC/SAU-BEB/105650/2008 and PTDC/EME-MFE/099109/2008) from the Science and Technology Foundation (FCT), FEDER and COMPETE, Portugal.

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Correspondence to Vera Faustino .

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Faustino, V. et al. (2014). Flow of Red Blood Cells Suspensions Through Hyperbolic Microcontractions. In: Lima, R., Imai, Y., Ishikawa, T., Oliveira, M. (eds) Visualization and Simulation of Complex Flows in Biomedical Engineering. Lecture Notes in Computational Vision and Biomechanics, vol 12. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7769-9_9

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  • DOI: https://doi.org/10.1007/978-94-007-7769-9_9

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  • Publisher Name: Springer, Dordrecht

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  • Online ISBN: 978-94-007-7769-9

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