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Cellular and Molecular Control of Neuronal Migration pp 59–74Cite as

Novel Functions of Core Cell Cycle Regulators in Neuronal Migration

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 800))

Abstract

The cerebral cortex is one of the most intricate regions of the brain, which required elaborated cell migration patterns for its development. Experimental observations show that projection neurons migrate radially within the cortical wall, whereas interneurons migrate along multiple tangential paths to reach the developing cortex. Tight regulation of the cell migration processes ensures proper positioning and functional integration of neurons to specific cerebral cortical circuits. Disruption of neuronal migration often lead to cortical dysfunction and/or malformation associated with neurological disorders. Unveiling the molecular control of neuronal migration is thus fundamental to understand the physiological or pathological development of the cerebral cortex. Generation of functional cortical neurons is a complex and stratified process that relies on decision of neural progenitors to leave the cell cycle and generate neurons that migrate and differentiate to reach their final position in the cortical wall. Although accumulating work shed some light on the molecular control of neuronal migration, we currently do not have a comprehensive understanding of how cell cycle exit and migration/differentiation are coordinated at the molecular level. The current chapter tends to lift the veil on this issue by discussing how core cell cycle regulators, and in particular p27Kip1 acts as a multifunctional protein to control critical steps of neuronal migration through activities that go far beyond cell cycle regulation.

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Acknowledgements

We would like to apologize to all authors whose work could not be cited du to length restrictions. L.N. is Research Associate from the Belgian National Funds for Scientific Research (F.R.S- F.N.R.S.). His laboratory is funded by grants from the F.R.S.- F.N.R.S., the Fonds Léon Fredericq, the Fondation Médicale Reine Elisabeth, the Belgian Science Policy (IAP-VII network P7/20), ARC (ARC11/16-01), the Walloon excellence in lifesciences and biotechnology (WELBIO). J.G. has been awarded Marie-Curie and EMBO long-term fellowships.

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Authors and Affiliations

  1. GIGA-Neurosciences, University of Liège, C.H.U. Sart Tilman, Liège, 4000, Belgium

    Juliette D. Godin & Laurent Nguyen

  2. Interdisciplinary Cluster for Applied Genoproteomics (GIGA-R), University of Liège, C.H.U. Sart Tilman, Liège, 4000, Belgium

    Juliette D. Godin & Laurent Nguyen

  3. Wallon Excellence in Lifesciences and Biotechnology (WELBIO), University of Liège, C.H.U. Sart Tilman, Liège, 4000, Belgium

    Laurent Nguyen

Authors
  1. Juliette D. Godin
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  2. Laurent Nguyen
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Correspondence to Laurent Nguyen .

Editor information

Editors and Affiliations

  1. GIGA-Neurosciences, University of Liège, Liège, Belgium

    Laurent Nguyen

  2. Institute of Science and Technology Austria, Klosterneuburg, Niederösterreich, Austria

    Simon Hippenmeyer

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© 2014 Springer Science+Business Media Dordrecht

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Godin, J.D., Nguyen, L. (2014). Novel Functions of Core Cell Cycle Regulators in Neuronal Migration. In: Nguyen, L., Hippenmeyer, S. (eds) Cellular and Molecular Control of Neuronal Migration. Advances in Experimental Medicine and Biology, vol 800. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7687-6_4

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