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Toxicology Evaluation and Properties of a New Biodegradable Computer Made Medical Biomaterial

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Frontier and Future Development of Information Technology in Medicine and Education

Part of the book series: Lecture Notes in Electrical Engineering ((LNEE,volume 269))

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Abstract

Background Poly (propylene carbonate) (PPC) synthesized from carbon dioxide and propylene oxide has attracted considerable research attention recently. To explore the potential application of these new polymers for bone repair, it is necessary to use other biodegradable polymers to enhance the properties of PPC. Poly (3-hydroxybutyrate) was used in this study to modify the mechanical properties and biocompatibility of PPC. Methods Poly (propylene carbonate) (PPC) was melt-mixed with 30 % poly (3-hydroxybutyrate) to enhance its physical properties, while maintaining the inherently high structural integrity and ductility. The mechanical strength, porosity, morphologies and biocompatibility of porous modified-PPC (PM-PPC) were fully investigated using tensile tester, hammering method, scanning electron microscopy, cytotoxicity test for its biocompatibility. Results The PM-PPC was measured by mechanical tests for its compressive strength, elongation module and tensile strength, with the results being 43, 725 and 32 Mpa respectively. The data showed that the mechanical properties of PM-PPC were significantly improved compared with PPC. The mean porosity of PM-PPC was 15 %, as determined by hammering method. The biocompatibility test of PM-PPC showed that it has excellent potential for use as a biomedical material. Conclusions In conclusion, the PM-PPC showed improved mechanical properties, and an acceptable biocompatibility supporting its potential for use in patients. Thus, PM-PPC is a promising candidate for use as a novel medical material.

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Abbreviations

PPC:

Poly (propylene carbonate)

M-PPC:

Modified-poly (propylene carbonate)

PM-PPC:

Porous modified-poly (propylene carbonate)

GTR:

Guided tissue regeneration

P (3HB):

Poly (3-hydroxybutyrate)

PHB:

Poly (3-hydroxybutyrate)

PCL:

Poly (3-caprolactone)

PLA:

Poly (lactic acid)

PHBV:

Polyhydroxybutyrate Valerate

NMR:

Nuclear magnetic resonance

PO:

Propylene Oxide

GPC:

Gel permeation chromatography

SEM:

Scanning electron micrograph

OD:

Optical density

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Acknowledgments

This work was supported by the China National Science and Technology Support Program (grant number 2007BAE42B06). We thank Professor Rick C Nicholson at Mothers and Babies Research Center, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, Australia for his language assistance and structure design in this paper.

Competing interests

The authors declare that they have no competing interests.

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Authors and Affiliations

  1. Department of Pathogenobiology, Norman Bethune College of Medicine, Jilin University, 126 Xinmin Street, Changchun, 130021, People’s Republic of China

    Jinshu Ma, Chao Zhang, Jingying Sai, Guangyu Xu, Xiaotian Zhang, Chao Feng, Fan Li & Fang Wang

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  1. Jinshu Ma
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  2. Chao Zhang
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  8. Fang Wang
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Corresponding author

Correspondence to Fang Wang .

Editor information

Editors and Affiliations

  1. Cognitive Science, Xiamen University, Xiamen, People's Republic of China

    Shaozi Li

  2. Human Informatics and Cognitive Sciences, Waseda University Networked Information Systems Lab, Waseda, Japan

    Qun Jin

  3. School of Systems Information Science, Future University Hakodate, Hakodate, Hokkaido, Japan

    Xiaohong Jiang

  4. Department of Computer Science and Engineering, Seoul University of Science & and Technology (SeoulTech), Seoul, Korea, Republic of (South Korea)

    James J. (Jong Hyuk) Park

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Ma, J. et al. (2014). Toxicology Evaluation and Properties of a New Biodegradable Computer Made Medical Biomaterial. In: Li, S., Jin, Q., Jiang, X., Park, J. (eds) Frontier and Future Development of Information Technology in Medicine and Education. Lecture Notes in Electrical Engineering, vol 269. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7618-0_76

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  • DOI: https://doi.org/10.1007/978-94-007-7618-0_76

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  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-007-7617-3

  • Online ISBN: 978-94-007-7618-0

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