Toxicology Evaluation and Properties of a New Biodegradable Computer Made Medical Biomaterial

  • Jinshu Ma
  • Chao Zhang
  • Jingying Sai
  • Guangyu Xu
  • Xiaotian Zhang
  • Chao Feng
  • Fan Li
  • Fang Wang
Conference paper
Part of the Lecture Notes in Electrical Engineering book series (LNEE, volume 269)

Abstract

Background Poly (propylene carbonate) (PPC) synthesized from carbon dioxide and propylene oxide has attracted considerable research attention recently. To explore the potential application of these new polymers for bone repair, it is necessary to use other biodegradable polymers to enhance the properties of PPC. Poly (3-hydroxybutyrate) was used in this study to modify the mechanical properties and biocompatibility of PPC. Methods Poly (propylene carbonate) (PPC) was melt-mixed with 30 % poly (3-hydroxybutyrate) to enhance its physical properties, while maintaining the inherently high structural integrity and ductility. The mechanical strength, porosity, morphologies and biocompatibility of porous modified-PPC (PM-PPC) were fully investigated using tensile tester, hammering method, scanning electron microscopy, cytotoxicity test for its biocompatibility. Results The PM-PPC was measured by mechanical tests for its compressive strength, elongation module and tensile strength, with the results being 43, 725 and 32 Mpa respectively. The data showed that the mechanical properties of PM-PPC were significantly improved compared with PPC. The mean porosity of PM-PPC was 15 %, as determined by hammering method. The biocompatibility test of PM-PPC showed that it has excellent potential for use as a biomedical material. Conclusions In conclusion, the PM-PPC showed improved mechanical properties, and an acceptable biocompatibility supporting its potential for use in patients. Thus, PM-PPC is a promising candidate for use as a novel medical material.

Keywords

Porous modified-PPC Composites Mechanical properties 

Abbreviation List

PPC

Poly (propylene carbonate)

M-PPC

Modified-poly (propylene carbonate)

PM-PPC

Porous modified-poly (propylene carbonate)

GTR

Guided tissue regeneration

P (3HB)

Poly (3-hydroxybutyrate)

PHB

Poly (3-hydroxybutyrate)

PCL

Poly (3-caprolactone)

PLA

Poly (lactic acid)

PHBV

Polyhydroxybutyrate Valerate

NMR

Nuclear magnetic resonance

PO

Propylene Oxide

GPC

Gel permeation chromatography

SEM

Scanning electron micrograph

OD

Optical density

Notes

Acknowledgments

This work was supported by the China National Science and Technology Support Program (grant number 2007BAE42B06). We thank Professor Rick C Nicholson at Mothers and Babies Research Center, Hunter Medical Research Institute, John Hunter Hospital, Newcastle, Australia for his language assistance and structure design in this paper.

Competing interests

The authors declare that they have no competing interests.

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Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  • Jinshu Ma
    • 1
  • Chao Zhang
    • 1
  • Jingying Sai
    • 1
  • Guangyu Xu
    • 1
  • Xiaotian Zhang
    • 1
  • Chao Feng
    • 1
  • Fan Li
    • 1
  • Fang Wang
    • 1
  1. 1.Department of PathogenobiologyNorman Bethune College of Medicine, Jilin UniversityChangchunPeople’s Republic of China

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