Relating Research on ADC Value and Serum GGT, TBil of Lesions in Neonatal Hypoxic Ischemic Encephalopathy

Abstract

Objective Combined with neonatal hypoxic-ischemic encephalopathy (HIE) lesions’ images in DWI, the ADC value, serum GGT, and the TBil content to provide the basis for the early diagnosis and treatment of HIE. Materials and Methods To detect serum GGT and TBil of 27 cases of HIE patients who were born in 24–48 h and adept MRI examination in one week, and measure the ADC value of the lesion. 30 healthy newborns were chosen randomly as control group. Result (1) Lesions’ ADC value in neonatal HIE patients was significantly lower than that in normal neonatal (P < 0.05). There are no difference between mild and moderate HIE patient’s ADC value (P > 0.05). ADC value of the severe lesions was lower than that in mild and moderate patients (P < 0.05). (2) Serum GGT values of severe HIE patients were higher than those of mild and moderate patients. NSE of moderate HIE patients was higher than that of mild patients (P < 0.05). Serum TBil of severe HIE were lower than that of mild and moderate patients (P < 0.05). Serum TBil of moderate HIE were lower than that of mild patients (P < 0.05). (3) the severe HIE patients’ DWI images with high signal lesions were more than in mild and moderate patients, moderate HIE patients’ DWI images with high signal lesions were more than mild patients (P < 0.05). Conclusion we can combine HIE patients’ DWI images, lesion’s ADC values and serum GGT, TBil level to use for early diagnosis of neonatal hypoxic-ischemic encephalopathy.