Simulating the Space Deep Brain Stimulations Using a Biophysical Model
In this paper, A computational biophysical model of basal ganglia (BG) thalamic (TC) network is introduced to assess the influence of space deep brain stimulation (DBS) on motor symptoms of Parkinson’s disease (PD). In PD state, the firing of globus pallidus in pars interna (GPi) is burstlike and synchronized. If the standard DBS current is applied, the tonic rhythm output of GPi could restore the TC relay properties. Under the consideration of space stimulation, the firing patterns of BG-TC network are similar to the standard DBS. These results demonstrate that the single-compartmental, conductance-based network model can simulate space electrical stimulation into the brain.
KeywordsParkinson’s disease (PD) Deep brain stimulation (DBS) Space stimulation Basal ganglia thalamic network
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