A Preliminary Study of the Influence of T-2 Toxin on the Expressions of Bcl-2 and Bax of Ameloblasts in Rat’s Incisor

  • Sha-fei Zhai
  • Zhu Yong
  • Ma Zheng
  • Yaochao Zhang
Conference paper
Part of the Lecture Notes in Electrical Engineering book series (LNEE, volume 269)


To investigate the effects of T-2 toxin on the protein expression of Bcl-2/Bax of ameloblast in rat’s incisor. 30 Wistar rats were divided randomly into 3 groups: control, low dose and high dose T-2 toxin poisoning group. After 4 weeks treatment, immunohisto-chemistry was used to observe the relative intensity of Bax and Bcl-2 expression in the ameloblasts. Quantitative analysis of the expression of Bax and Bcl-2 was performed with a computer image analysis system. Quantitative analysis showed the Bax protein expression was up-regulated, the Bcl-2 protein expression was down-regulated, and the Bax/Bcl-2 expression ratio was up-regulated in the secretory-stage ameloblasts treated with T-2 toxin, and this was significant between three groups (P < 0.05). Thus, T-2 toxin can decrease the expression of Bcl-2 and increase the expression of Bax in the secretory-stage ameloblasts of rat’s incisor. With the increase of T-2 toxin exposure dose, this effect is much marked.


T-2 toxin Rat Ameloblast 



This research was supported through funding from Scientific Research Program funded by Shaanxi Provincial Education Department (Program No. 12JK0763).


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Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  • Sha-fei Zhai
    • 1
  • Zhu Yong
    • 1
  • Ma Zheng
    • 2
  • Yaochao Zhang
    • 2
  1. 1.Department of Oral MedicineXi’an Medical UniversityXi’anChina
  2. 2.Department of Public HealthXi’an medical universityXi’anChina

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