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Prediction of Three-Dimensional Structure of PPARγ Transcript Variant 1 Protein

  • Cong Sun
  • Qiang Wu
  • Ye-chao Han
  • Ting-ting Tang
  • Li-li Wang
Conference paper
Part of the Lecture Notes in Electrical Engineering book series (LNEE, volume 269)

Abstract

To predict three-dimensional structure and binding site of ligand from amino acid sequence of peroxisome proliferator-activated receptor gamma(PPARγ) transcript variant 1 protein. The secondary structure and surface properties of PPARγ transcript variant 1 protein such as hydrophilicity, physical and chemical properties, surface probability, flexible regions, motif, transmembrane domain, signal peptide and secondary structure were analyzed to predict its binding site of ligand by bioinformatics methods and means. Many potential binding sites of ligand were identified. Conclusion The secondary structure and binding site of ligand of PPARγ transcript variant 1 protein were predicted successfully by multiparameter. This study provided a foundation for identification of its advantage binding site of ligand and understanding its biological functions on the basis of protein structure.

Keywords

PPARγ Transcript variant 1 protein Binding site of ligand Motif 

References

  1. 1.
    Brown J, Plutzky J (2007) Peroxisome Proliferator-activated receptors as transcriptional nodal points and the rapeutietargets. Circulation 115:518–533CrossRefGoogle Scholar
  2. 2.
    Glass CK, Ogawa S (2006) Combinatorial roles of nuclear receptors in inflammation and immunity. Nat Rev Immunol 6:44–55CrossRefGoogle Scholar
  3. 3.
    Lehrke M, Lazar MA (2005) The many faces of PPARgamma. Cell 123(6):993–999Google Scholar
  4. 4.
    Jing K, Bei CH, Lei J (2010) PPAR signal transduction pathway in the foam cell formation induced byvisfatin. Acta Physiol Sin 62:27–432Google Scholar
  5. 5.
    Heikkinen S, Auwerx J (2007) Argmann CA.PPARgamma in human and mouse physiology. Biochim BioPhys Acta 1771:999–1013Google Scholar
  6. 6.
    Tu S, Chen K, Zhong L-P et al (2010) Structural analysis and antigenic epitope prediction of snake venom C type lectin family proteins. Chin J Immunol 50:963–972Google Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  • Cong Sun
    • 1
  • Qiang Wu
    • 2
  • Ye-chao Han
    • 3
  • Ting-ting Tang
    • 1
  • Li-li Wang
    • 1
  1. 1.Changchun University of Chinese MedicineChangchunChina
  2. 2.Department of Chinese MedicineChina-Japan Union Hospital Jilin UniversityChangchunChina
  3. 3.Jilin Institute for Veterinary Drug and Feed ControlChangchunChina

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