Bioinformatics Prediction of the Tertiary Structure for the Emy162 Antigen of Echinococcus multilocularis

  • Yanhua Li
  • Xianfei Liu
  • Yuejie Zhu
  • Xiaoan Hu
  • Song Wang
  • Xiumin Ma
  • Jianbing Ding
Conference paper
Part of the Lecture Notes in Electrical Engineering book series (LNEE, volume 269)

Abstract

We wanted to determine the dominant epitopes of the Emy162 antigen, the secondary and the tertiary structure for the Emy162 antigen found in Echinococcus multilocularis. To do so, we analyzed the secondary structure and the tertiary structure of Emy162 protein. We used online software called Phyre2 Server to predict the secondary structure and 3DLigandsite for the tertiary structure of Emy162 protein. From the server we found that the random coil and the β-sheet accounted for approximately 40 % of secondary structure. After the bioinformatics analysis, the secondary and tertiary structures provided us important information for developing a vaccine using the dominant epitopes. This was an indication that it works as a potent dominant antigenic epitopes in Emy162 anatigen.

Keywords

Emy162 Secondary structure Tertiary structure Bioinformatics 

Notes

Acknowledgements

This study was supported by the National Nature Science Foundation of China (81160378, 81160200, 81060135 and 30860263).

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Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  • Yanhua Li
    • 1
  • Xianfei Liu
    • 1
  • Yuejie Zhu
    • 1
  • Xiaoan Hu
    • 2
  • Song Wang
    • 1
    • 3
  • Xiumin Ma
    • 3
  • Jianbing Ding
    • 1
    • 2
  1. 1.National Clinical Research Base of Traditional Chinese Medicine of Xinjiang Medical UniversityXinjiangChina
  2. 2.College of Basic Medicine, Xinjiang Medical UniversityXinjiangChina
  3. 3.State Key Laboratory Incubation Base of Major Diseases in Xinjiang and Xinjiang Key Laboratory of EchinococcosisFirst Affiliated Hospital of Xinjiang Medical UniversityXinjiangChina

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