Study the Effect of Different Traditional Chinese Medicine Treatment which to the Elasticity Modulus of Asthma Rats’ Lung
Elasticity modulus is the most important and most characteristic of the mechanical properties which express the degree of materials. The work aimed to explore the changes of elasticity modulus in asthma rats lung and the effect of different Traditional Chinese Medicine (TCM) treatment, such as lung-diffusing therapy, body resistance-strengthening therapy, integrated therapy of lung-diffusing and body resistance-strengthening, to them. We copied rat asthma model using ovalbumin, then gavaged treatment with three Chinese medicine, After 4 weeks, we researched the changes of modulus elasticity in asthma rats lung based on the biological elasticity modulus detection system, and researched the impact of three TCM treatment to them. We found the elasticity modulus of rats lung in normal group is less than those in other groups, and there is statistically significant difference between normal group and model group, prednisone group, body resistance-strengthening group. There also is statistically significant difference between prednisone group and the combination of lung-diffusing and body resistance-strengthening group. TCM treatment can improve the elastic modulus of asthmatic rats lung, and it probable is one of the mechanisms of the treatment of asthma.
KeywordsAsthma Elasticity modulus Traditional Chinese medicine treatment Mechanism of effect
This study is supported by the National Natural Science Foundation of China (No.81072787), the National Natural Science Foundation of Shanghai (No.10ZR1429900) and Key Discipline of State Administration of Traditional Chinese Medicine (Chinese diagnostics).
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