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Effect of T Lymphocytes PD-1/B7-H1 Path Expression in Patients with Severe Hepatitis Depression from Promoting Liver Cell Growth Hormone Combinations from Gongying Yinchen Soup

  • Zhang Junhui
  • Gao Junfeng
  • Zhao Xinguo
  • Li Meng
  • Ma Limin
  • Hou Jinjie
  • Sun Yanfu
  • Gu Qing
  • Li Ruiyu
Conference paper
Part of the Lecture Notes in Electrical Engineering book series (LNEE, volume 269)

Abstract

Objective To investigate the effect of T lymphocytes PD-1/B7-H1 path expression in patients with severe hepatitis depression from promoting liver cell growth hormone combinations from Gongying Yinchen soup. Methods With reference to the American psychiatric association’s diagnostic statistical manual of mental disorders, fourth edition (dsm-iv) criteria, 88 cases of fulminant hepatitis in patients with depression were collected as treatment group, which consist of acute severe hepatitis (n = 31), chronic severe hepatitis (n = 28) and subacute severe hepatitis (n = 29),120 mg promoting liver cell growth hormone to join within 250 ml of 10 % glucose injection, intravenous drip, 1 times a day, 15 d for a period of treatment, At the same time to add with the Gongying Yinchen soup (dandelion, radix et rhizoma rhei, radix bupleuri, herba artemisiae capillaris, glabrous greenbrier rhizome, radix isatidis, grifola, bitter arguments). Three period of treatment. Thirty healthy persons of control group come from blood donor of central blood stations. The expressions of PD-1/B7-H1 of T lymphocytes and T lymphocyte subsets of two groups were determined by flow cytometry. Results The positive expression of PD1 and B7—H1of T lymphocytes in patients of the treatment group was significant higher than that in healthy control group (P < 0.05); The positive expression of PD1and B7—H1of T lymphocytes significantly decreased after treatment in the treatment group (P < 0.05). The amount of CD4+, CD8+ cells of the treatment group was significantly lower than that of control group (P < 0.05). The amount of CD4+/CD8+ cells of the treatment group was higher than that of control group (P < 0.05), significantly decreased after treatment (P < 0.05). Conclusion Promoting liver cell growth hormone combination from the Gongying Yinchen soup can influence expression of T lymphocytes PD-1/B7-H1 path in patients with severe hepatitis depression, enhance the body’s immune response.

Keywords

Hepatocyte growth-promoting factors Gongying yinchen soup Severe hepatitis T lymphocyte PD-1/B7-H1 

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Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  • Zhang Junhui
    • 1
  • Gao Junfeng
    • 2
  • Zhao Xinguo
    • 3
  • Li Meng
    • 4
  • Ma Limin
    • 3
  • Hou Jinjie
    • 1
  • Sun Yanfu
    • 2
  • Gu Qing
    • 2
  • Li Ruiyu
    • 5
  1. 1.Xingtai Medical CollegeXingtaiChina
  2. 2.Second affiliated hospitalXingtai Medical CollegeXingtaiChina
  3. 3.Chinese Medicine Hospital of Lincheng CountyTangshanChina
  4. 4.Health Team of Hotan Prefecture Detachment of Chinese Armed Police ForceXinjiangChina
  5. 5.Institute of Integrated Traditional and Western Medicine, second affiliated hospitalXingtai Medical CollegeXingtaiChina

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