Skip to main content

The Influence of Short Chain Fatty Acids on Biosynthesis of Emodin by Aspergillus ochraceus LP-316

  • Conference paper
  • First Online:
  • 134 Accesses

Part of the book series: Lecture Notes in Electrical Engineering ((LNEE,volume 269))

Abstract

Emodin or 1,3,8-trihydroxy-6-methyl-anthraquinone is a naturally occurring pigment found in many plants, molds and lichens. Our previous studies revealed that a strain of Aspergillus ochraceus LP-316 (from LP-118 isolated from Chinese potato) had produced emodin efficiently. In this article, the production of emodin in 5-L bioreactor and resting cells system was studied with adding short chain fatty acids as precursors in order to identified the biosynthesis pathway type of emodin. The result illustrated that acetic acid was propitious to enhance the content of emodin and provided valuable information for the further searching the biosynthesis mechanism of emodin.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   429.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   549.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   549.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Izhaki I (2002) Emodin—a secondary metablosite with multiple ecological functions in higher plants. New Phytol 55:205−217

    Google Scholar 

  2. Lin SY, Lai WW, Ho CC et al (2009) Emodin induces apoptosis of human tongue squamous cancer SCC-4 cells through reactive oxygen species and mitochondria-dependent pathways. Anticancer Res 29:327–335

    Google Scholar 

  3. Muto A, Hori M, Sasaki Y et al (2007) Emodin has a cytotoxic activity against human multiple myeloma as a janus-activated kinase 2 inhibitor. Mol Cancer Ther 6:987–994

    Article  Google Scholar 

  4. Srinivas G, Babykutty S, Sathiadevan PP et al (2007) Molecular mechanism of emodin action: transition from laxative ingredient to an antitumor agent. Med Res Rev 591−608

    Google Scholar 

  5. Ding Y, Zhao L, Mei H et al (2008) Exploration of emodin to treat alpha-naphthylisothiocyanate-induced cholestatic hepatitis via anti-inflammatory pathway. Eur J Pharmacol. 590:377 − 386

    Google Scholar 

  6. Wang L, Li D, Bao C et al (2008) Ultrasonic extraction and separation of anthraquinones from rheum palmatum L. Ultrason Sonochem 15:738−746

    Google Scholar 

  7. Kaneshiro T, Morioka T, Inamine M et al (2006) Anthraquinone derivative emodin inhibits tumor-associated angiogenesis through inhibition of extracellular signal-regulated kinase 1/2 phosphorylation. Eur J Pharmacol 553:46–53

    Article  Google Scholar 

  8. Zhang L, Lau YK, Xia W et al (1999) Tyrosine kinase inhibitor emodin suppresses growth of her-2/neu-overexpressing breast cancer cells in athymic mice and sensitizes these cells to the inhibitory effect of paclitaxel. Clin Cancer Res 5:343–353

    Google Scholar 

  9. Lu P, Zhao XM, Cui T (2010) Production of emodin from Aspergillus ochraceus at preparative scale. Afican J Biotechnol 9(4):512–517

    Google Scholar 

  10. Smetanska I (2008) Production of secondary metabolites using plant cell cultures. Adv Biochem Eng Biotechnol 111:187–228

    Google Scholar 

  11. Tumova L, Gallova K, Rimakova J (2004) Silybum marianum in vitro. Ceska Slov Farm 53(3):135–140

    Google Scholar 

Download references

Acknowledgments

The financial support of Tianjin Natural Science Foundation (A Study of Biosynthesis Pathway and Induced Mechanism from Reactive Oxygen Species of Emodin by Fermentation from Aspergillus ochraceus, No: 12JCYBJC19000), is gratefully Acknowledged.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Lv Ping .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2014 Springer Science+Business Media Dordrecht

About this paper

Cite this paper

Li, X., Ping, L. (2014). The Influence of Short Chain Fatty Acids on Biosynthesis of Emodin by Aspergillus ochraceus LP-316. In: Li, S., Jin, Q., Jiang, X., Park, J. (eds) Frontier and Future Development of Information Technology in Medicine and Education. Lecture Notes in Electrical Engineering, vol 269. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7618-0_287

Download citation

  • DOI: https://doi.org/10.1007/978-94-007-7618-0_287

  • Published:

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-007-7617-3

  • Online ISBN: 978-94-007-7618-0

  • eBook Packages: EngineeringEngineering (R0)

Publish with us

Policies and ethics