Change of Plasma Adrenomedullin and Expression of Adrenomedullin and its Receptor in Villus of Normal Early Pregnancy

  • Lihong Ruan
  • Zhenghui Fang
  • Jingxia Tian
  • Yan Dou
  • Wenyu Zhong
  • Xiue Song
  • Wei Shi
  • Aiying Lu
  • Lizhi Sun
  • Guihua Jia
  • Haifeng Yu
  • Shuyi Han
  • Hongqiao Wu
Conference paper
Part of the Lecture Notes in Electrical Engineering book series (LNEE, volume 269)

Abstract

Objective To study the role of adrenomedullin (ADM) in normal early pregnancy. Method Plasma concentrations of ADM were measured in 30 normal early pregnancy and 30 non-pregnant women (control group) by radioimmunoassay. The expression of ADM, ADM mRNA and ADMR mRNA in villi of normal early pregnancy were determined by immunohistochemistry and in situ hybridization respectively. Results The Plasma concentration of ADM in normal early pregnancy was significantly higher than that of control group (22.735 + 2.382 ng/l vs. 15.800 + 3.142 ng/l, P < 0.05). The expressions of ADM, ADM mRNA and ADMR mRNA in villi of normal early pregnancy were found in the cytoplasm and cell membrane of the syncytiotrophoblast and cytotrophoblast. Conclusion During human normal early pregnancy, plasma ADM was involved in the regulation of maternal homeostasis, and villus ADM might contribute to trophoblasts invasion and vasculogenesis.

Keywords

Early pregnancy Adrenomedullin RNA Messenger 

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Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  • Lihong Ruan
    • 1
  • Zhenghui Fang
    • 1
  • Jingxia Tian
    • 1
  • Yan Dou
    • 1
  • Wenyu Zhong
    • 1
  • Xiue Song
    • 1
  • Wei Shi
    • 1
  • Aiying Lu
    • 1
  • Lizhi Sun
    • 1
  • Guihua Jia
    • 1
  • Haifeng Yu
    • 1
  • Shuyi Han
    • 1
  • Hongqiao Wu
    • 1
  1. 1.Jinan Central HospitalShandong UniversityJinanChina

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