Meta-Analysis of Chinese Herbs in the Treatment of Nephropathy: Huangqi and Danggui Type Formulations

Conference paper
Part of the Lecture Notes in Electrical Engineering book series (LNEE, volume 269)

Abstract

Objective Numerous Chinese patients with Diabetic nephropathy (DN) have benefited from chinese herbs. However, there is no systematic evaluation about them. Methods We conducted a meta-analysis to all eligible randomized clinical trials (RCTs) to assess the effect of Chinese herbs on DN for the first time. Results (1) Five eligible RCTs with 356 participants; (2) Chinese herbs brought a favorable increase in total remission (TR) (RR2.60, 95 %CI 1.55 to4.34, I2 = 0 %) compared with non-Chinese herbs treatment; (3) Exploiting subgroup meta-analysis, Chinese herbs led to significantly improvements of DN with ACEI treatment with regard to the decrease of urinary proteinuria excretion (UPE) (MD −23.65 ug/min, 95 % CI −29.37 to −17.92, I2 = 0 %) Conclusion Chinese herbs was certainly a valuable and promising treatment remedy for DN.

Keywords

Diabetic nephropathy Chinese herbs Drug therapy Meta-analysis 

Notes

Acknowledgments

The work is supported by the grant from the Natural Science Foundation of China (No. 81273723).

References

  1. 1.
    Fang C, Jing-tao D (2012) Insulin selections ofdiabetic nephropath. J Drug Evalution 9:21–25Google Scholar
  2. 2.
    Ling Q (2006) New treatment progress of diabetic nephropathy. Foreign Med Geriatr Med 27:16–19Google Scholar
  3. 3.
    Mei-ru L, Qing-feng G, Xi-jun F (2005) Clinical observation on efficaly of jiawei danggui buxue decoction in treating 46 patients with diabetic nephropathy in clinical stage. Chinese J Pract Chinese Mod Med 28:572–573Google Scholar
  4. 4.
    Xue-lan Zh, Zhao-yun Q, Jin-ling W et al (2007) Clinical observation on efficaly of huangqi danggui decoction compasing with benazepril in treating patients with diabetic nephropathy. Clin Focus 22:131–132Google Scholar
  5. 5.
    Xue-lan Zh, Song-juan L, Lin-lin Zh et al (2007) Huangqi danggui decoction in treating patients with diabetic nephropathy. Chinese Tradit Pat Med 29:641–644Google Scholar
  6. 6.
    Shi-yun L, Dao-kuan L, Su-pu N (2008) Huangqi danggui decoction in treating patients with diabetic nephropathy. J New Chinese Med 40:21–22Google Scholar
  7. 7.
    Cui-fen G, Xiao-li Q, Jing-hua W et al (2009) Danggui buxue decoction and benazepril in treating patients with diabetic nephropathy at erarlier stage. Shanxi Chinese Med 30:974–976Google Scholar
  8. 8.
    Ling-yun Y, Shu-yu Y, Xue-jun L (2012) Research progress of the control mechanisms of astragalus polysaccharides on diabetic nephropathy. Med Recapitulate 18:172–1728Google Scholar
  9. 9.
    Li CR, Cai F, Yang YQ et a1 (2010) Tetrahydroxystilbene glucoside ameliorates diabetic nephropathy in rats:involvement of S1RT1 and TGF-B1 pathway. Eur J Pharmacol 649:382–389Google Scholar
  10. 10.
    Ming-gang W, Li N, Ling Zh et al (2012) protecion mechansms of modified danggui buxue decoction for podocytes in adriamycin-induced nephropathy rats. Chin J Integr Med 32:1077–1087Google Scholar
  11. 11.
    Cover-smith A, Hendry BM (2008) The regulation of mesangial cell proliferation. Nephron Exp Nephrol 108:e74–e79CrossRefGoogle Scholar
  12. 12.
    Tahara A, Tsukada J, Tomura Y et a1(2008) Effect of vasopressin on type IV collagen production in human mesangial cells. Regul Pept 147:60–66Google Scholar
  13. 13.
    Ming-gang W, Wei S, Pei-hua X et al (2012) Antifibrotic effect of the Chinese herbs modified danggui buxue decoction on adriamycin-induced nephropathy in rats. Chin J Integr Med 18:591–598Google Scholar
  14. 14.
    Ming-gang W, Pei-hua X, Ling Zh (2013) Effect of Chinese herbs on immunoglobulin A nephropathy: a randomized controlled trial. J Tradit Chinese Med 33:65–69Google Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  1. 1.The First Affiliated Hospital of Soochow UniversitySuzhouChina

Personalised recommendations