Comparison of Intravenous Propofol Using Target-Controlled Infusion and Inhalational Sevoflurane Anesthesia in Pediatric Patients

Conference paper
Part of the Lecture Notes in Electrical Engineering book series (LNEE, volume 269)


Propofol is used for the hypnotic effect and is characterized by a short onset of action and a prompt recovery from anesthesia. The target-controlled infusion system can administer drugs to patients more precisely and consistently. Sevoflurane is a popular inhalational anesthetic for general anesthesia in children. We conducted this study to compare the intravenous propofol using TCI system and inhalational sevoflurane anesthesia in pediatric patients. We collected clinical data of 128 pediatric patients who were underwent surgery from February, 2011 to February 2013 in the First Hospital of Jilin University. Patients were randomly assigned into two groups of either propofol TCI (group P, n = 64) and sevoflurane (group S, n = 64) using a computer generated randomization list. All patients were monitored with an electrocardiogram (ECG), non-invasive blood pressure (BP) and pulse oxygen saturation (SPO2). Patients in group P received an intravenous propofol infusion using a TCI system. Patients in group S received inhalational sevoflurane anesthesia. There was a significant difference between the two groups in hemodynamic variables after anesthesia and intubation and the group P decreased greater than group S (P < 0.05). There was significant difference in the time of loss of consciousness, intubation, recovery of spontaneous respiration, and the cases of respiration depression between two groups (P < 0.05). The time of loss of consciousness and intubation was longer in the group S than the group P (P < 0.05). But the time of recovery of spontaneous respiration and consciousness was shorter in group S (P < 0.05). There was less cases of respiration depression in group S (P < 0.05). Both of the groups can provide satisfied anesthesia and have their own advantages and disadvantages. We should make good use of the doses of the infusion or inhalation of anesthetic drugs.


Anesthesia Propofol Sevoflurane Pediatric 


  1. 1.
    Allegaert K, de Hoon J, Verbesselt R (2007) Maturational pharmacokinetics of single intravenous bolus of propofol. J Paediatr Anaesth 17:1028–1034CrossRefGoogle Scholar
  2. 2.
    Anderson BJ (2010) Pediatric models for adult target-controlled infusion pumps. J Pediatric Anesthesia 20:223–232CrossRefGoogle Scholar
  3. 3.
    Cohen IT, Finkel JC, Hannallah RS, Hummer KA, Patel KM (2003) Rapid emergence does not explain agitation following sevoflurane anaesthesia in infants and children: a comparison with propofol. J Paediatr Anaesth 13:63–67CrossRefGoogle Scholar
  4. 4.
    Hu C, Horstman DJ, Shafer SL (2005) Variability of target-controlled infusion is less than the variability afterbolus injection. J Anaesthesiology 102:639–645CrossRefGoogle Scholar
  5. 5.
    Jeleazcov C, Ihmsen H, Schmidt J (2008) Pharmacodynamic modelling of the bispectral index response to propofol-based anaesthesia during general surgery in children. J Anaesth 100(4):509–516CrossRefGoogle Scholar
  6. 6.
    Munoz HR, Cortinez LI, Ibacache ME (2006) Effect site concentrations of propofol producing hypnosis in children and adults: comparison using the bispectral index. J Acta Anaesthesiol Scand 50:882–887CrossRefGoogle Scholar
  7. 7.
    Kuratani Norifumi, Oi Yumiko (2008) Greater incidence of emergence agitation in children after sevoflurane anesthesia as compared with halothane. J Anesthesiology 109:225–232CrossRefGoogle Scholar
  8. 8.
    Daniel Mellon R, Simone Arthur F, Rappaport Bob A (2007) Use of anesthetic agents in neonates and young children. J Pediatric Anesthesia 104:509–520Google Scholar
  9. 9.
    Saint-Maurice C, Cockshott ID, Douglas EJ (1989) Pharmacokinetics of propofol in young children after a single dose. Br J Anaesth 63:667–670CrossRefGoogle Scholar
  10. 10.
    Schultheis LW, Mathis LL, Roca RA (2006) Pediatric drug development in anesthesiology: an FDA perspective. J Anesth Analg 103:49–51CrossRefGoogle Scholar
  11. 11.
    Schuttler J, Ihmsen H (2000) Population pharmacokinetics of propofol: a multicenter study. J Anesthesiology 92:727–738CrossRefGoogle Scholar
  12. 12.
    Voepel-Lewis T, Malviya S, Tait AR (2003) A prospective cohort study of emergence agitation in the pediatric postanesthesia care unit. J Anesth Analg 96:1625–1630CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  • Dong Su
    • 1
  • Haichun Ma
    • 1
  • Wei Han
    • 1
  • Limin Jin
    • 1
  • Jia Liu
    • 2
  1. 1.Department of AnesthesiaThe First Hospital of Jilin UniversityChangchunChina
  2. 2.Department of Thyroid SurgeryThe First Hospital of Jilin UniversityChangchunChina

Personalised recommendations