Effect of Jiangtang Fonglong Capsule on Expressions of Insulin of Deaf Animal Models of Diabetes

  • Ruiyu Li
  • Kaoshan Guo
  • Lizhen Tang
  • Yanzhuo Zhang
  • Meng Li
  • Bin Li
Conference paper
Part of the Lecture Notes in Electrical Engineering book series (LNEE, volume 269)

Abstract

Objective: To observe the influence of jiangtang fanglong capsule to hearing impairment in deaf diabetes animal models. 50 Wistar rats randomly selected from 60 Wistar rats. The other 10 rats were normal control group (group A). 50 Wistar rats with experimental deaf diabetic, induced by 55 mg/kg streptozotocin (STZ) once intraperitoneal, were randomly divided into five groups. And the five groups contain model control group (group B), lower density (3.3 g/kg. d) jiangtang fanglong capsule was administrated (group C), middle density (310 g/kg. d) jiangtang fanglong capsule was administrated (group D), high density (3.3 g/kg. d) jiangtang fanglong capsule was administrated (group E) and yuquanwan (25 g/kg. d) was administrated (group F). After 60 days, test the fasting blood glucose (FBG), body weight (BW) and fasting insulin (FINS) of the wistar rats. Calculate the HO-MA-IR and HOMA-B, insulin was measured by radioimmunoassay. Tests showed that compared with model group, Jiangtang Fanglong capsule in middle and high dose groups reduce the index of the animal models in a dose-dependent manner (P < 0.05, P > 0.01), the HOMA-β shrink as the dose increased (P < 0.05, P > 0.01), improve the insulin expression in pancreatic islets (P < 0.05, P > 0.01), compare group E to B, it doesn’t make any sense (P > 0.05). Our results suggest that Jiangtang Fanglong capsule could improve the pancreatic β-cell’s function of the diabetic deaf animal model.

Keywords

Jiangtang Fanglong capsule Diabetic Deafness Wistar rats Streptozocin 

References

  1. 1.
    Li RY, Guo KS, Guo WY (2012) The influence of Jiangtang Fanglong capsule on diabetes accompanied with deafness in different syndrome on the hypothalamic-pituitary-adrenal axis. Int J Tradit Chin Med 34(2):1117–1118Google Scholar
  2. 2.
    Li RY, Wu LP, Song N et al (2000) TCM treatment of diabetic hearing loss-an audiological and rheological observation. J Tradit Chin Med 20(3):176–179Google Scholar
  3. 3.
    Li RY, Li M, Wang R, Li B et al (2008) Jiang Tang Fang Long Jiao Nang in treating non-insulin dependent Diabetes Mellitus with hearing loss. J Otol 3(1):45–50Google Scholar
  4. 4.
    Li RY, Guo YL, Liu JW (2011) The effect of Chinese kidney-tonifying drugs on diabetes deafness. Mod J Integr Tradit Chin West Med 20(6):654–656Google Scholar
  5. 5.
    Wang SL, Chen XM, Bi DZ (2004) Study on preparation of experimental hearing impaired diabetes animal model induced by Streptozotocin. J Audiol Speech Pathol 12(6):402–403Google Scholar
  6. 6.
    Yu DM, Wu Y, Yin H (1995) A study on experimental diabetes an imalmodels induced by streptozotoein. Chin J Diab 3(2):105Google Scholar
  7. 7.
    Hanffer SM, Kennedy E, Gonzalez C et al (1996) A prospective analysis of the HOMA model: the mexico city diabetes study. Diabetes Care 19:1138–1141CrossRefGoogle Scholar
  8. 8.
    Lee NK, Sowa H, Hinoi E et al (2007) Endocine regulation of energy metabolism by the skeleton. Cell 130(3):409–411CrossRefGoogle Scholar
  9. 9.
    Ferron M, Hinoi E, Karsenty G et al (2008) Osteocalcin differentially regulates beta cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice. Proc Natl Acad Sci USA 105(13):5266–5270Google Scholar
  10. 10.
    Shen ZY, Chen Y, Huang JH (2006) Syndrome differentiation through drug effects in mapping the two regulatory pathway of gene networks in Shen deficiency syndrome. Chin J Integr Tradit West Med 26(6):521–525Google Scholar
  11. 11.
    Li RY, Li M, Guo YL (2011) The influence of Jiangtang Fanglong capsule on diabetes accompanied with deafness in different syndrome on the osteocalcin. J New Chin Med 43(2):32–33Google Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  • Ruiyu Li
    • 1
  • Kaoshan Guo
    • 2
  • Lizhen Tang
    • 2
  • Yanzhuo Zhang
    • 2
  • Meng Li
    • 3
  • Bin Li
    • 4
  1. 1.Institute of Integrated Traditional and Western MedicineSecond Affiliated Hospital, Xingtai Medical CollegeXingtaiChina
  2. 2.Second Affiliated Hospital of Xingtai Medical CollegeXingtaiChina
  3. 3.Health Team of Hotan Prefecture Detachment of Chinese Armed Police Force in XinjiangHotanChina
  4. 4.Department of BiochemistryHebei Medical UniversityShijiazhuangChina

Personalised recommendations