Present study is ready to detect the expression of tumor gene PTEN and the cell cycle depended on kinase inhibitor P16 in bladder carcinoma through immunohistochemical method, and analyze the relation between them and the tumor grade or phase, and exame the correlation of the expression of these two proteinsin bladder carcinoma. It is found that the positive rates of PTEN and P16 protein expression in normal bladder mucosa tissue were higher than in bladder transitional cell carcinoma, and are correlated with pathological grade, the clinical stage and lymph nodes metastasis of BTCC. The expressions of PTEN are positively related to that of P16. They play synergistic action in the occurrence and development of BTCC.
BTCC PTEN protein P16 protein
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