Advertisement

The Association Analysis of P16 in Transitional Cell

Conference paper
Part of the Lecture Notes in Electrical Engineering book series (LNEE, volume 269)

Abstract

Present study is ready to detect the expression of tumor gene PTEN and the cell cycle depended on kinase inhibitor P16 in bladder carcinoma through immunohistochemical method, and analyze the relation between them and the tumor grade or phase, and exame the correlation of the expression of these two proteinsin bladder carcinoma. It is found that the positive rates of PTEN and P16 protein expression in normal bladder mucosa tissue were higher than in bladder transitional cell carcinoma, and are correlated with pathological grade, the clinical stage and lymph nodes metastasis of BTCC. The expressions of PTEN are positively related to that of P16. They play synergistic action in the occurrence and development of BTCC.

Keywords

BTCC PTEN protein P16 protein 

References

  1. 1.
    Fults D, Pedone CA, Thomas GA (1990) Allelotype of human malignant astrocytoma. Cancer Res 50:5784–5789Google Scholar
  2. 2.
    Rahseed BK, Fuller GN, Friendman AH (1992) Loss of heterozygosity for 10q loci in human glioma. Genes Chromo Cancer 5:75–78CrossRefGoogle Scholar
  3. 3.
    Gray IC, Phillips SM, Lee SJ (1995) Loss of chromosomal region 10q23–25 in prostate cancer. Cancer Res 55:4800–4848Google Scholar
  4. 4.
    Li J, Yen C, Liaw D (1997) PTEN, a putive protein tyrosine phosphatase gene mutated in human brain, breast and prostate cancer. Science 275:1943–1947CrossRefGoogle Scholar
  5. 5.
    Nevins JR (1992) E2F: a link between the Rb tumor suppressor protein and vival oncoproteins. Science 258:424–429CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  1. 1.Department of Obstetrics and GynecologyGeneral Hospital of Wuhan Iron and Steel CorporationWuhanChina

Personalised recommendations