Metastatic Oligodendroglioma: Diagnosis with Fine-Needle Aspiration Cytology
Extracranial/systemic metastasis of a primary central nervous system glial tumor is very rare, but the incidence is ever-increasing. Oligodendroglial tumors are uncommon; however, after high-grade astrocytomas, they constitute an important group of tumors which are reported to cause extracranial metastases. In the majority of literature-reported cases, the likelihood of a second primary tumor is considered as the first approach; therefore metastases are overlooked. Fine-needle aspiration cytology (FNAC) is currently accepted as a reliable, accurate, cost-effective and rapid diagnostic method for possible metastatic lesions in a patient with known primary tumor. FNAC findings of metastatic oligodendroglioma and small-round-cell tumors (SRCT) are quite similar, therefore differential diagnosis requires combination of the clinical and radiological data. In addition, application of immunochemistry and detection of 1p/19q co-deletion on cytological material confirm the diagnosis.
KeywordsGlial Fibrillary Acidic Protein Oligodendroglial Tumor Extracranial Metastasis Mesenchymal Chondrosarcoma Small Cell Neuroendocrin Carcinoma
- Reifenberger G, Kros JM, Louis DN, Collins VP (2007) Oligodendroglial tumours. In: Louis DN, Ohgaki H, Wiestler OD, Cavenee WK (eds) WHO classification of tumours of the central nervous system. International Agency for Research on Cancer Press, Lyon, pp 53–67Google Scholar