Metastatic Oligodendroglioma: Diagnosis with Fine-Needle Aspiration Cytology

Chapter
Part of the Tumors of the Central Nervous System book series (TCNS, volume 13)

Abstract

Extracranial/systemic metastasis of a primary central nervous system glial tumor is very rare, but the incidence is ever-increasing. Oligodendroglial tumors are uncommon; however, after high-grade astrocytomas, they constitute an important group of tumors which are reported to cause extracranial metastases. In the majority of literature-reported cases, the likelihood of a second primary tumor is considered as the first approach; therefore metastases are overlooked. Fine-needle aspiration cytology (FNAC) is currently accepted as a reliable, accurate, cost-effective and rapid diagnostic method for possible metastatic lesions in a patient with known primary tumor. FNAC findings of metastatic oligodendroglioma and small-round-cell tumors (SRCT) are quite similar, therefore differential diagnosis requires combination of the clinical and radiological data. In addition, application of immunochemistry and detection of 1p/19q co-deletion on cytological material confirm the diagnosis.

Keywords

Glial Fibrillary Acidic Protein Oligodendroglial Tumor Extracranial Metastasis Mesenchymal Chondrosarcoma Small Cell Neuroendocrin Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Anand M, Kumar R, Jain P, Gupta R, Ghosal N, Sharma A, Agarwal A, Sharma MC (2003) Metastatic anaplastic oligodendroglioma simulating acute leukemia. A case report. Acta Cytol 47:467–469PubMedCrossRefGoogle Scholar
  2. Bruggers C, White K, Zhou H, Chen Z (2007) Extracranial relapse of an anaplastic oligodendroglioma in an adolescent: case report and review of the literature. J Pediatr Hematol Oncol 29:319–322PubMedCrossRefGoogle Scholar
  3. Budka H (1986) Non-glial specificities of immunocytochemistry for the glial fibrillary acidic protein (GFAP). Triple expression of GFAP, vimentin and cytokeratins in papillary meningioma and metastasizing renal carcinoma. Acta Neuropathol 72:43–54PubMedCrossRefGoogle Scholar
  4. Campbell BA, Horsman DE, Maguire J, Young S, Curman D, Ma R, Thiessen B (2008) Chromosomal alterations in oligodendroglial tumours over multiple surgeries: is tumour progression associated with change in 1p/19q status? J Neurooncol 89:37–45PubMedCrossRefGoogle Scholar
  5. Can B, Akpolat I, Meydan D, Üner A, Kandemir B, Söylemezoğlu F (2012) Fine-needle aspiration cytology of metastatic oligodendroglioma: case report and literature review. Acta Cytol 56:97–103PubMedCrossRefGoogle Scholar
  6. Choon A, Roepke JE (2004) Importance of immunohistochemical staining in metastatic anaplastic oligodendroglioma. Arch Pathol Lab Med 128:489–490PubMedGoogle Scholar
  7. Cordiano V, Miserocchi F, Storti M (2011) Bone marrow metastases from anaplastic oligodendroglioma presenting with pancytopenia and hypogammaglobulinemia: a case report. Tumori 97:808–811PubMedGoogle Scholar
  8. Dawson TP (1997) Pancytopaenia from a disseminated anaplastic oligodendroglioma. Neuropathol Appl Neurobiol 23:516–520PubMedCrossRefGoogle Scholar
  9. Giordana MT, Ghimenti C, Leonardo E, Balteri I, Iudicello M, Duò D (2004) Molecular genetic study of a metastatic oligodendroglioma. J Neurooncol 66:265–271PubMedCrossRefGoogle Scholar
  10. Hulbanni S, Goodman PA (1976) Glioblastoma multiforme with extraneural metastases in the absence of previous surgery. Cancer 37:1577–1583PubMedCrossRefGoogle Scholar
  11. James TG, Pagel W (1951) Oligodendroglioma and extracranial metastases. Br J Surg 39:56–65PubMedCrossRefGoogle Scholar
  12. Jellinger K (2009) Metastatic oligodendrogliomas: a review of the literature and case report. Acta Neurochir (Wien) 151:987CrossRefGoogle Scholar
  13. Jellinger K, Minauf M, Salzer-Kuntschik M (1969) Oligodendroglioma with extraneural metastases. J Neurol Neurosurg Psychiatry 32:249–253PubMedCentralPubMedCrossRefGoogle Scholar
  14. Kojima H, Mori K, Fukudome N, Iseki M, Shimizu S (2008) Cytologic characteristics of intracytoplasmic refractile eosinophilic granular bodies in anaplastic oligodendroglioma: a case report. Acta Cytol 52:467–470PubMedCrossRefGoogle Scholar
  15. Krijnen JL, Fleischeur RE, van Berkel M, Westenend PJ (2010) Metastatic oligodendroglioma: a case report and incidence in The Netherlands. Clin Neuropathol 29:141–146PubMedCrossRefGoogle Scholar
  16. Lee CC, Jiang JS, Chen ET, Yokoo H, Pan YH, Tsai MD (2006) Cytologic diagnosis of a metastatic oligodendroglioma in a pleural effusion. A case report. Acta Cytol 50:542–544PubMedCrossRefGoogle Scholar
  17. Liwnicz BH, Rubinstein LJ (1979) The pathways of extraneural spread in metastasizing gliomas: a report of three cases and critical review of the literature. Hum Pathol 10:453–467PubMedCrossRefGoogle Scholar
  18. Lopez-Rios F, Alberti N, Ballestin C, Pérez-Barrios A, de Agustín P (2000) Extracranial metastases of a glioma: diagnosis by fine needle aspiration and immunocytochemistry. Diagn Cytopathol 23:43–45PubMedCrossRefGoogle Scholar
  19. Macdonald DR, O’Brien RA, Gilbert JJ, Cairncross JG (1989) Metastatic anaplastic oligodendroglioma. Neurology 39:1593–1596PubMedCrossRefGoogle Scholar
  20. Merrell R, Nabors LB, Perry A, Palmer CA (2006) 1p/19q chromosome deletions in metastatic oligodendroglioma. J Neurooncol 80:203–207PubMedCrossRefGoogle Scholar
  21. Mitsuhashi T, Shimizu Y, Ban S, Ogawa F, Matsutani M, Shimizu M, Hirose T (2007) Anaplastic oligodendroglioma: a case report with characteristic cytologic features, including minigemistocytes. Acta Cytol 51:657–660PubMedCrossRefGoogle Scholar
  22. Morrison T, Bilbao JM, Yang G, Perry JR (2004) Bony metastases of anaplastic oligodendroglioma respond to temozolomide. Can J Neurol Sci 31:102–108PubMedGoogle Scholar
  23. Ng WH, Lim TC, Tan KK (2006) Disseminated spread of recurrent oligodendroglioma (WHO grade II). J Clin Neurosci 13:602–607PubMedCrossRefGoogle Scholar
  24. Noshita N, Mashiyama S, Fukawa O, Asano S, Watanabe M, Tominaga T (2010) Extracranial metastasis of anaplastic oligodendroglioma with 1p19q loss of heterozygosity – case report. Neurol Med Chir (Tokyo) 50:161–164CrossRefGoogle Scholar
  25. Ohgaki H, Kleihues P (2005) Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas. J Neuropathol Exp Neurol 64:479–489PubMedGoogle Scholar
  26. Ordonez NG, Ayala AG, Leavens ME (1981) Extracranial metastases of oligodendroglioma: report of a case and review of the literature. Neurosurgery 8:391–396PubMedCrossRefGoogle Scholar
  27. Perry A (2004) Metastatic oligodendroglioma: a mini-epidemic? Adv Anat Pathol 11:325CrossRefGoogle Scholar
  28. Reifenberger G, Kros JM, Louis DN, Collins VP (2007) Oligodendroglial tumours. In: Louis DN, Ohgaki H, Wiestler OD, Cavenee WK (eds) WHO classification of tumours of the central nervous system. International Agency for Research on Cancer Press, Lyon, pp 53–67Google Scholar
  29. Uzuka T, Kakita A, Inenaga C, Takahashi H, Tanaka R, Takahashi H (2007) Frontal anaplastic oligodendroglioma showing multi-organ metastases after a long clinical course. Case report. Neurol Med Chir (Tokyo) 47:174–177CrossRefGoogle Scholar
  30. Volavsek M, Lamovec J, Popović M (2009) Extraneural metastases of anaplastic oligodendroglial tumors. Pathol Res Pract 205:502–507PubMedCrossRefGoogle Scholar
  31. Wang M, Murphy KM, Kulesza P, Hatanpaa KJ, Olivi A, Tufaro A, Erozan Y, Westra WH, Burger PC, Berg KD (2004) Molecular diagnosis of metastasizing oligodendroglioma: a case report. J Mol Diagn 6:52–57PubMedCentralPubMedCrossRefGoogle Scholar
  32. Watson CW, Hajdu SI (1977) Cytology of primary neoplasms of the central nervous system. Acta Cytol 21:40–47PubMedGoogle Scholar
  33. Wu Y, Liu B, Qu L, Tao H (2011) Extracranial skeletal metastasis in anaplastic oligodendroglioma: case report and review of the literature. J Int Med Res 39:960–967PubMedCrossRefGoogle Scholar
  34. Zustovich F, Della Puppa A, Scienza R, Anselmi P, Furlan C, Cartei G (2008) Metastatic oligodendrogliomas: a review of the literature and case report. Acta Neurochir (Wien) 150:699–703CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  1. 1.Department of Pathology, School of MedicineOndokuz Mayis UniversitySamsunTurkey

Personalised recommendations