Neonatal Hypoxic-Ischemic Brain Damage: Human Umbilical Cord Blood Mononuclear Cells Transplantation

  • Pedro M. Pimentel-Coelho
  • Rosalia Mendez-Otero
Part of the Tumors of the Central Nervous System book series (TCNS, volume 13)


In the last decades, a great effort has been made to understand the physiopathology of neonatal hypoxic-ischemic encephalopathy (HIE), the main cause of long-term neurological impairments in term neonates. This effort was recently marked by a landmark advance in the treatment of HIE, represented by the significant neuroprotective effect of therapeutic hypothermia, in an example of successful translation of preclinical research findings to the bedside. However, at least 40% of the cooled infants will still die or have moderate/severe neurological disability, indicating that newer therapies are absolutely necessary. In this regard, umbilical cord blood mononuclear cells (UCBC), which are readily available for transplantation in the first hours after birth, have been shown to improve the neurological function when transplanted in several models of brain injury, including HIE. In this chapter we give a concise overview of recent studies evaluating the potential therapeutic role of UCBC transplantation in animal models of HIE. We also discuss the potential mechanisms underlying the action of these cells in the newborn brain and the current effort to translate these observations to patients in several ongoing clinical trials.


Mesenchymal Stem Cell Cerebral Palsy Umbilical Cord Blood Therapeutic Hypothermia Cord Blood Bank 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  • Pedro M. Pimentel-Coelho
    • 1
  • Rosalia Mendez-Otero
    • 1
  1. 1.Instituto de Biofísica Carlos Chagas FilhoUniversidade Federal do Rio de JaneiroRio de JaneiroBrazil

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