The Role of Hyaluronic Acid and Its Receptors in the Growth and Invasion of Brain Tumors

  • Yushan Kim
  • Sanjay KumarEmail author
Part of the Tumors of the Central Nervous System book series (TCNS, volume 13)


Malignant gliomas induce a complex cascade of changes in the extracellular matrix of the brain during their growth and invasion. This chapter highlights those changes involving hyaluronic acid, a glycosaminoglycan that constitutes much of the brain extracellular matrix, and the biophysical and biochemical effects those changes have on glioma cells. Signaling effects of hyaluronic acid receptors will be discussed, with a focus on CD44. The implications of CD44 enrichment in cancer stem cells will be discussed. Finally, because these interactions are highly dependent on the cellular microenvironment, we will review various in vitro cell culture platforms that have been used to model glioma cell motility and invasion.


Hyaluronic Acid Glioma Cell Cancer Stem Cell Focal Adhesion Kinase Malignant Peripheral Nerve Sheath Tumor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  1. 1.Department of Bioengineering and California, Institute for Quantitative BiosciencesUniversity of CaliforniaBerkeleyUSA

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