The Role of Hyaluronic Acid and Its Receptors in the Growth and Invasion of Brain Tumors
Malignant gliomas induce a complex cascade of changes in the extracellular matrix of the brain during their growth and invasion. This chapter highlights those changes involving hyaluronic acid, a glycosaminoglycan that constitutes much of the brain extracellular matrix, and the biophysical and biochemical effects those changes have on glioma cells. Signaling effects of hyaluronic acid receptors will be discussed, with a focus on CD44. The implications of CD44 enrichment in cancer stem cells will be discussed. Finally, because these interactions are highly dependent on the cellular microenvironment, we will review various in vitro cell culture platforms that have been used to model glioma cell motility and invasion.
KeywordsHyaluronic Acid Glioma Cell Cancer Stem Cell Focal Adhesion Kinase Malignant Peripheral Nerve Sheath Tumor
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