Resection of Brain Tumors: Intraoperative Confocal Microscopy Technology
The ability to diagnose brain tumors in vivo and reliably identify tumor margins in the course of resection are two innovations that could impact the neurosurgical oncologist’s ability to maximize resection and minimize morbidity. Recent advances in optical imaging and miniaturization have enabled the production of a hand-held intraoperative confocal microscope. We present a first-look feasibility analysis of the intraoperative confocal microscope as an adjunct for brain tumor resection. Intraoperative confocal microscopy is an emerging and practicable technology for the resection of human brain tumors. Our preliminary assessment indicates the reliability of this technique for a variety of lesions in identifying tumor cell populations, as well as the tumor-brain interface, in situ. Further refinement of this technology may depend upon the approval of tumor-specific fluorescent contrast agents for human use.
KeywordsCentral Neurocytomas Optical Biopsy Anaplastic Transformation Glioma Surgery Meningothelial Meningioma
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