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The Role of Hsp70s in the Development and Pathogenicity of Plasmodium Species

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Heat Shock Proteins of Malaria

Abstract

The development of malaria parasite in the human host is characterized with challenges and for this reason the parasite employs several strategies to ensure its survival. It is generally known that parasites tend to express heat shock proteins (Hsps) in response to adverse conditions that they encounter in host cells. Heat shock proteins play an important role in proteostasis as their main role is to stabilize proteins and to refold misfolded proteins, particularly in the wake of physiological stress. The genome of the main agent of malaria P. falciparum encodes 6 Hsp70 proteins: cytosol-localised (PfHsp70-1/PF3D7_0818900 and PfHsp70-z/PF3D7_0708800); endoplasmic reticulum-based (PfHsp70-2/PF3D7_0917900 and PfHsp70-y/PF3D7_1344200); mitochondrial (PfHsp70-3/ PF3D7_1134000) and one that is exported to the infected erythrocyte (PfHsp70-x/PF3D7_0831700). The general role of Hsp70 proteins is to prevent and to reverse protein misfolding. However, Hsp70s are also capable of facilitating protein trafficking. This chapter constitutes a review of the role of this proteins in the survival of the parasite as well as their function at the host-parasite interface. What is apparent is that these proteins play an important role as house-keepers in the parasite cell. However, their role extends beyond the confines of the parasite cell, regulating both survival and pathogenesis of malaria parasites.

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Acknowledgements

Funding for this work has been received from the funding from the Deutsche Forschungsgemeinschaft (DFG) German-African Cooperation Projects in Infectology grant (Ref: LI 402/14-1) and the University of Zululand. The author is grateful to the Alexander von Humboldt Foundation (Germany) for the award of a Georg Foster Research Fellowship.

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  1. Department of Biochemistry & Microbiology, University of Zululand, KwaDlangezwa, South Africa

    Addmore Shonhai

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  1. Dept. of Biochemistry and Microbiology, University of Zululand, KwaDlangezwa, South Africa

    Addmore Shonhai

  2. College of Health and Biomedicine, Victoria University, Melbourne, Victoria, Australia

    Gregory L. Blatch

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Shonhai, A. (2014). The Role of Hsp70s in the Development and Pathogenicity of Plasmodium Species. In: Shonhai, A., Blatch, G. (eds) Heat Shock Proteins of Malaria. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7438-4_3

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