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Biology

  • Marco Fioroni
  • Tamara Dworeck
  • Francisco Rodríguez-Ropero
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 794)

Abstract

This chapter will be an introductory section on the biology of membrane proteins in general, with regard to the different structural as well as functional classes of these proteins (i.e. α-helix and β-barrel). It will furthermore give some basic information on biological membranes and the lipids they consist of. The focus will be on the characteristics and unique structural and functional features of β-barrel outer membrane proteins. This chapter will then introduce to the E. coli outer membrane iron transporter FhuA (Ferric hydroxamate uptake component A), which as a member of the TonB protein-dependent transporters belongs to the largest known β-barrels. The FhuA has been successfully employed as a model for the transformation of a β-barrel protein into a custom-made nano-channel. By means of the FhuA example this chapter will therefore look at β-barrel proteins not only within the biological context but it will already introduce to the relevance and use of proteins belonging to this class for the nano-material sciences and specifically for the design of biological nano-channels.

Keywords

Outer Membrane Transmembrane Helix Polar Amino Acid Peripheral Protein Membrane Span Helix 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  • Marco Fioroni
    • 1
  • Tamara Dworeck
    • 2
  • Francisco Rodríguez-Ropero
    • 3
  1. 1.Sustainable MomentumAachenGermany
  2. 2.Department of BiologyRWTH Aachen UniversityAachenGermany
  3. 3.Center of Smart InterfacesTechnische Universität DarmstadtDarmstadtGermany

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