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Molecular Pathology and Diagnostics of Childhood Tumors

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Molecular Pathology and Diagnostics of Cancer

Part of the book series: Cancer Growth and Progression ((CAGP,volume 16))

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Abstract

Neoplasms in the fetus and infant are discussed in reference to types, incidence, clinical features, behavior, and response to treatment. Tumors that occur predominately in the first year of life have certain features of embryonic growth, including Wilms’ tumors, neuroblastomas, embryonic sarcomas, yolk sac tumors of the testis, hepatoblastomas, and medulloblastomas of the brain, as well as sacrococcygeal tumors that have an overgrowth of embryonic components. Chromosome translocations, tumor suppressor genes, and some syndromes and congenital malformations associated with childhood tumors are discussed.

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Abbreviations

ARMS:

Alveolar rhabdomyosarcoma

BWS:

Beckwith-Wiedemann syndrome

CHEK2:

Checkpoint kinase 2

CN:

Cystic nephroma

CNS:

Central nervous system

ERMS:

Embryonal rhabdomyosarcoma

EWS:

Ewing sarcoma

FAP:

Familial adenomatous polyposis

FISH:

Fluorescent in situ hybridization

GIST:

Gastrointestinal stromal tumors

HPV:

Human papilloma virus

IGF2:

Insulin-like growth factor II

MEN1:

Multiple endocrine neoplasia type 1

MEN2:

Multiple endocrine neoplasia type 2

NF1:

Neurofibromatosis type 1

NF2:

Neurofibromatosis type 2

PDGF:

Platelet-derived growth factor

PNET:

Primitive neuroectodermal tumor

PTCH:

Patch

RT-PCR:

Reverse transcription-polymerase chain reaction

SHH:

Sonic hedgehog

SMO:

Smoothened

VHL:

Von Hippel-Lindau

WAGR syndrome:

Wilms’ tumor, aniridia, genitourinary abnormalities and mental retardation

WT-1:

Wilms’ tumor-1 gene product

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Authors and Affiliations

  1. Department of Pathology and Cell Biology, Pediatrics and Obstetrics and Gynecology, University of South Florida College of Medicine at Tampa General Hospital, Tampa, FL, USA

    Enid Gilbert-Barness

  2. University of South Florida College of Medicine at Tampa General Hospital, Tampa, FL, USA

    Kristen Eisbrenner

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  1. Enid Gilbert-Barness
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Correspondence to Enid Gilbert-Barness .

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Editors and Affiliations

  1. Anatomic Pathology, University of South Florida, Moffitt Cancer Center, Tampa, Florida, USA

    Domenico Coppola

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Gilbert-Barness, E., Eisbrenner, K. (2014). Molecular Pathology and Diagnostics of Childhood Tumors. In: Coppola, D. (eds) Molecular Pathology and Diagnostics of Cancer. Cancer Growth and Progression, vol 16. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7192-5_15

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