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Molecular Pathology and Diagnostics of Gynecologic Malignancies

  • Rodney E. Shackelford
  • Masoumeh Ghayouri
  • Domenico Coppola
  • Ardeshir HakamEmail author
Chapter
Part of the Cancer Growth and Progression book series (CAGP, volume 16)

Abstract

Gynecologic malignancies account for roughly 13 % of solid tissue tumors in women. Many of these malignancies, such as many ovarian tumors, first present at an advanced stage, making them difficult to treat. Until recently the analysis of these malignancies was largely limited to hematoxylin-eosin-stained slide examination, supplemented with immunohistochemical stains. Recently, molecular diagnostic techniques have been applied to these tumors with some success, especially with BRCA1/2 mutations and Lynch syndrome analyses. Here, we describe the present molecular diagnostic tests applied to gynecologic malignancies and discuss possible future developments in this field.

Keywords

Gynecologic malignancies HPV BRCA1 BRCA2 Mole Nampt Ovary Vulva Fallopian tubes Vagina Lynch syndrome Endometrium 

Abbreviations

CDK

Cyclin-dependent protein kinase

dsDNA

Double-stranded DNA

EST

Endometrial stromal tumor

FDA

US Food and Drug Administration

HNPCC

Hereditary nonpolyposis colorectal cancer

HPV

Human papilloma virus

HRM

High-resolution melting analysis

MMMT

Malignant mixed mullerian tumor

Nampt

Nicotinamide phosphoribosyltransferase

PCR

Polymerase chain reaction

PJS

Peutz-Jeghers syndrome

UCCC

Uterine clear cell carcinoma

UEA

Uterine endometrial adenocarcinoma

USC

Uterine serous carcinoma

Notes

Acknowledgement

We would like to thank Miss Jennifer Burton for her help in manuscript preparation and proof reading.

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Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  • Rodney E. Shackelford
    • 1
  • Masoumeh Ghayouri
    • 2
  • Domenico Coppola
    • 2
  • Ardeshir Hakam
    • 2
    Email author
  1. 1.Department of Pathology and Laboratory MedicineTulane University School of MedicineNew OrleansUSA
  2. 2.Department of PathologyH. Lee Moffitt Cancer Center and Research InstituteTampaUSA

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