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Tissue Engineering pp 149–178Cite as

Photocrosslinkable Materials for the Fabrication of Tissue-Engineered Constructs by Stereolithography

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Part of the book series: Computational Methods in Applied Sciences ((COMPUTMETHODS,volume 31))

Abstract

Stereolithography is an additive technique that produces three-dimensional (3D) solid objects using a multi-layer procedure through the selective photo-initiated curing reaction of a liquid photosensitive material. Stereolithographic processes have been widely employed in Tissue Engineering for the fabrication of temporary constructs, using natural and synthetic polymers, and polymer-ceramic composites. These processes allow the fabrication of complex structures with a high accuracy and precision at physiological temperatures, incorporating cells and growth factors without significant damage or denaturation. Despite recent advances on the development of novel biomaterials and biocompatible crosslinking agents, the main limitation of these techniques are the lack number of available photocrosslinkable materials, exhibiting appropriate biocompatibility and biodegradability. This chapter gives an overview of the current state-of-art of materials and stereolithographic techniques to produce constructs for tissue regeneration, outlining challenges for future research.

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Acknowledgements

This work was supported by the Portuguese Foundation for Science and Technology through the projects PTDC/EME-PME/098037/2008 and Pest-OE/EME/UI4044/2011.

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  1. Centre for Rapid and Sustainable Product Development (CDRsp), Polytechnic Institute of Leiria, Leiria, Portugal

    Rúben F. Pereira & Paulo J. Bártolo

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Correspondence to Paulo J. Bártolo .

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  1. Instituto Superior Tecnico Mechanical Engineering Dept., Technical University of Lisbon, Grande Lisboa, Portugal

    Paulo Rui Fernandes

  2. CDRSP – IP Leiria Portugal, Marinha Grande, Portugal

    Paulo Jorge Bartolo

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© 2014 Springer Science+Business Media Dordrecht

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Pereira, R.F., Bártolo, P.J. (2014). Photocrosslinkable Materials for the Fabrication of Tissue-Engineered Constructs by Stereolithography. In: Fernandes, P., Bartolo, P. (eds) Tissue Engineering. Computational Methods in Applied Sciences, vol 31. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7073-7_8

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  • DOI: https://doi.org/10.1007/978-94-007-7073-7_8

  • Publisher Name: Springer, Dordrecht

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  • Online ISBN: 978-94-007-7073-7

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