Photocrosslinkable Materials for the Fabrication of Tissue-Engineered Constructs by Stereolithography

Part of the Computational Methods in Applied Sciences book series (COMPUTMETHODS, volume 31)

Abstract

Stereolithography is an additive technique that produces three-dimensional (3D) solid objects using a multi-layer procedure through the selective photo-initiated curing reaction of a liquid photosensitive material. Stereolithographic processes have been widely employed in Tissue Engineering for the fabrication of temporary constructs, using natural and synthetic polymers, and polymer-ceramic composites. These processes allow the fabrication of complex structures with a high accuracy and precision at physiological temperatures, incorporating cells and growth factors without significant damage or denaturation. Despite recent advances on the development of novel biomaterials and biocompatible crosslinking agents, the main limitation of these techniques are the lack number of available photocrosslinkable materials, exhibiting appropriate biocompatibility and biodegradability. This chapter gives an overview of the current state-of-art of materials and stereolithographic techniques to produce constructs for tissue regeneration, outlining challenges for future research.

Keywords

Tissue Engineering Application Hydrogel Scaffold Ceramic Scaffold Trimethylene Carbonate Methyl Ether Methacrylate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

This work was supported by the Portuguese Foundation for Science and Technology through the projects PTDC/EME-PME/098037/2008 and Pest-OE/EME/UI4044/2011.

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Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  1. 1.Centre for Rapid and Sustainable Product Development (CDRsp)Polytechnic Institute of LeiriaLeiriaPortugal

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