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Tissue Engineering pp 113–128Cite as

Optimization Approaches for the Design of Additively Manufactured Scaffolds

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Part of the book series: Computational Methods in Applied Sciences ((COMPUTMETHODS,volume 31))

Abstract

Scaffolds play a pivotal role in tissue engineering, promoting the synthesis of neo extra-cellular matrix (ECM), and providing temporary mechanical support for the cells during tissue regeneration. Advances introduced by additive manufacturing techniques have significantly improved the ability to regulate scaffold architecture, enhancing the control over scaffold shape and porosity. Thus, considerable research efforts have been devoted to the fabrication of 3D porous scaffolds with optimized micro-architectural features. This chapter gives an overview of the methods for the design of additively manufactured scaffolds and their applicability in tissue engineering (TE). Along with a survey of the state of the art, the Authors will also present a recently developed method, called Load-Adaptive Scaffold Architecturing (LASA), which returns scaffold architectures optimized for given applied mechanical loads systems, once the specific stress distribution is evaluated through Finite Element Analysis (FEA).

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Author information

Authors and Affiliations

  1. Tissue Engineering Laboratory, CIR-Center for Integrated Research, Università Campus Bio-Medico di Roma, via Alvaro del Portillo 21, 00128, Rome, Italy

    Sara M. Giannitelli, Alberto Rainer & Marcella Trombetta

  2. Biomedical Robotics and Biomicrosystems Laboratory, CIR-Center for Integrated Research, Università Campus Bio-Medico di Roma, via Alvaro del Portillo 21, 00128, Rome, Italy

    Dino Accoto & Eugenio Guglielmelli

  3. Biomatica Srl, via G. Peroni 442/444, 00131, Rome, Italy

    Stefano De Porcellinis

  4. Tissue Engineering and Biomaterials Unit, CEIT and Tecnun, University of Navarra, Manuel de Lardizábal 15, 20018, San Sebastián, Spain

    Elena M. De-Juan-Pardo

Authors
  1. Sara M. Giannitelli
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  2. Alberto Rainer
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  3. Dino Accoto
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  4. Stefano De Porcellinis
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  5. Elena M. De-Juan-Pardo
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  6. Eugenio Guglielmelli
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  7. Marcella Trombetta
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Editor information

Editors and Affiliations

  1. Instituto Superior Tecnico Mechanical Engineering Dept., Technical University of Lisbon, Grande Lisboa, Portugal

    Paulo Rui Fernandes

  2. CDRSP – IP Leiria Portugal, Marinha Grande, Portugal

    Paulo Jorge Bartolo

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Giannitelli, S.M. et al. (2014). Optimization Approaches for the Design of Additively Manufactured Scaffolds. In: Fernandes, P., Bartolo, P. (eds) Tissue Engineering. Computational Methods in Applied Sciences, vol 31. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-7073-7_6

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  • DOI: https://doi.org/10.1007/978-94-007-7073-7_6

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-007-7072-0

  • Online ISBN: 978-94-007-7073-7

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