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Glioblastoma Microvesicles Transport RNA and Proteins, Promoting Tumor Growth

  • David Gonda
  • Amit Goyal
  • Johnny Akers
  • Clark Chen
  • Bob Carter
Chapter
Part of the Tumors of the Central Nervous System book series (TCNS, volume 11)

Abstract

The recent discovery that tumor-derived proteins and nucleic acid are carried in nano-sized vesicles in the plasma of patients with brain tumors has expanded opportunities for biomarker discovery and therapeutics. Through delivery of their contents to surrounding cells, these small extra-cellular vesicles secreted by tumors including glioblastomas are able to modulate their environment to promote tumor growth and survival. In this chapter, we discuss the potential use of small microvesicles as sources of tumor-specific biomarkers, mediators of therapy, and treatment monitoring. We review the normal physiology of these vesicles, their characterization, and new directions for research in this interesting field.

Keywords

Glioblastoma Cell Intercellular Communication Extracellular Vesicle Rabies Viral Glycoprotein Exosome Isolation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  • David Gonda
    • 1
  • Amit Goyal
    • 1
  • Johnny Akers
    • 1
  • Clark Chen
    • 1
  • Bob Carter
    • 1
  1. 1.UCSD NeurosurgerySan DiegoUSA

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