Cranial Meningioma in Neurofibromatosis Type 2 Patients: Role of Mutations

  • Miriam J. Smith
  • D. Gareth R. Evans
Part of the Tumors of the Central Nervous System book series (TCNS, volume 11)


Meningiomas are the most common form of primary intracranial tumour in adults and are associated with the neurogenetic syndrome neurofibromatosis type 2 (NF2). Somatic mutations of the NF2 gene are found in the majority of both sporadic and NF2-associated meningiomas. With comprehensive genetic testing germline mutations can be identified in approximately 93 % of NF2 patients. The type and location of these mutations have both been shown to determine the risk of meningioma in these patients. It is also possible that sporadic and NF2 disease-associated meningiomas arise as a result of different pathological mechanisms.


Nonsense Mediate Decay Actin Binding Domain Ferm Domain Spinal Meningioma High Grade Meningioma 
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Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  1. 1.Department of Genetic Medicine, St. Mary’s Hospital, Manchester Academic Health Sciences CenterUniversity of ManchesterManchesterUK

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