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Involvement of Human Peroxisomes in Biosynthesis and Signaling of Steroid and Peptide Hormones

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Book cover Peroxisomes and their Key Role in Cellular Signaling and Metabolism

Part of the book series: Subcellular Biochemistry ((SCBI,volume 69))

Abstract

Although peroxisomes exert essential biological functions, cell type-specific features of this important organelle are still only superficially characterized. An intriguing new aspect of peroxisomal function was recently uncovered by the observation that the peptide hormones β-lipotropin (β-LPH) and β-endorphin are localized to peroxisomes in various human tissues. This suggests a functional link between peptide hormone metabolism and peroxisomes. In addition, because endocrine manifestations that affect steroid hormones are often found in patients suffering from inherited peroxisomal disorders, the question has been raised whether peroxisomes are also involved in steroidogenesis. With this chapter, we will review several crucial aspects concerning peroxisomes and hormone metabolism.

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Abbreviations

ABC-transporter:

ATP binding cassette transporter

ACTH:

Adrenocorticotropic Hormone

ALDP:

Adrenoleukodystrophy protein

DHEA:

Dehydroepiandrostenedione

IBA:

Indole-3-butyric acid

PC:

Prohormone convertase

POMC:

Proopiomelanocortin

TGN:

Trans-Golgi network

VLCFA:

Very long-chain fatty acids

X-ALD:

X-linked adrenoleukodystrophy

α-MSH:

α-Melanocyte-Stimulating Hormone

β-LPH:

β-Lipotropin

References

  • Akil H et al (1998) Endogenous opioids: overview and current issues. Drug Alcohol Depend 51:127–140

    Article  PubMed  CAS  Google Scholar 

  • Assies J et al (2003) Effect of dehydroepiandrosterone supplementation on fatty acid and hormone levels in patients with X-linked adrenoleucodystrophy. Clin Endocrinol (Oxf) 59:459–466

    Article  CAS  Google Scholar 

  • Benjannet S et al (1991) PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues. Proc Natl Acad Sci USA 88:3564–3568

    Article  PubMed  CAS  Google Scholar 

  • Berger J, Gärtner J (2006) X-linked adrenoleukodystrophy: clinical, biochemical and pathogenetic aspects. Biochim Biophys Acta 1763:1721–1732

    Article  PubMed  CAS  Google Scholar 

  • Brennemann W et al (1997) Testicular dysfunction in adrenomyeloneuropathy. Eur J Endocrinol 137:34–39

    Article  PubMed  CAS  Google Scholar 

  • Cappa M et al (2011) Is subclinical adrenal failure in adrenoleukodystrophy/ adrenomyeloneuropathy reversible? J Endocrinol Invest 34:753–756

    PubMed  CAS  Google Scholar 

  • Chiang JY (2004) Regulation of bile acid synthesis: pathways, nuclear receptors, and mechanisms. J Hepatol 40:539–551

    Article  PubMed  CAS  Google Scholar 

  • Dixit E et al (2010) Peroxisomes are signaling platforms for antiviral innate immunity. Cell 141:668–681

    Article  PubMed  CAS  Google Scholar 

  • Facciotti F et al (2012) Peroxisome-derived lipids are self antigens that stimulate invariant natural killer T cells in the thymus. Nat Immunol 13:474–480

    Article  PubMed  CAS  Google Scholar 

  • Ferdinandusse S et al (2009) Bile acids: the role of peroxisomes. J Lipid Res 50:2139–2147

    Article  PubMed  CAS  Google Scholar 

  • Halabe Bucay A (2008) The role of lipotropins as hematopoietic factors and their potential therapeutic use. Exp Hematol 36:752–754

    Article  PubMed  CAS  Google Scholar 

  • Höftberger R et al (2010) Peroxisomal localization of the proopiomelanocortin-derived peptides beta-lipotropin and beta-endorphin. Endocrinology 151:4801–4810

    Article  PubMed  Google Scholar 

  • Hogenboom S et al (2004a) Mevalonate kinase is a cytosolic enzyme in humans. J Cell Sci 117:631–639

    Article  PubMed  CAS  Google Scholar 

  • Hogenboom S et al (2004b) Phosphomevalonate kinase is a cytosolic protein in humans. J Lipid Res 45:697–705

    Article  PubMed  CAS  Google Scholar 

  • Jutras I et al (1997) Two activation states of the prohormone convertase PC1 in the secretory pathway. J Biol Chem 272:15184–15188

    Article  PubMed  CAS  Google Scholar 

  • Kou J et al (2011) Peroxisomal alterations in Alzheimer’s disease. Acta Neuropathol 122:271–283

    Article  PubMed  CAS  Google Scholar 

  • Kovacs WJ et al (2007) Localization of the pre-squalene segment of the isoprenoid biosynthetic pathway in mammalian peroxisomes. Histochem Cell Biol 127:273–290

    Article  PubMed  CAS  Google Scholar 

  • Lu JF et al (2007) The role of peroxisomal ABC transporters in the mouse adrenal gland: the loss of Abcd2 (ALDR), Not Abcd1 (ALD), causes oxidative damage. Lab Invest 87:261–272

    Article  PubMed  CAS  Google Scholar 

  • Mertani HC, Waters MJ, Morel G (1996) Cellular trafficking of exogenous growth hormone in dwarf rat pituitary. Neuroendocrinology 63:257–268

    Article  PubMed  CAS  Google Scholar 

  • Morel G (1994) Internalization and nuclear localization of peptide hormones. Biochem Pharmacol 47:63–76

    Article  PubMed  CAS  Google Scholar 

  • O’Connell Y, McKenna TJ, Cunningham SK (1996) beta-Lipotropin-stimulated adrenal steroid production. Steroids 61:332–336

    Article  PubMed  Google Scholar 

  • Petroni A et al (2000) Testosterone metabolites in patients reduce the levels of very long chain fatty acids accumulated in X-adrenoleukodystrophic fibroblasts. Neurosci Lett 289:139–142

    Article  PubMed  CAS  Google Scholar 

  • Powers JM (1980) A correlative study of the adrenal cortex in adreno-leukodystrophy–evidence for a fatal intoxication with very long chain saturated fatty acids. Invest Cell Pathol 3:353–376

    PubMed  CAS  Google Scholar 

  • Pritchard LE, White A (2007) Neuropeptide processing and its impact on melanocortin pathways. Endocrinology 148:4201–4207

    Article  PubMed  CAS  Google Scholar 

  • Stradomska TJ et al (2012) Reproductive function in men affected by X-linked adrenoleukodystrophy/adrenomyeloneuropathy. Eur J Endocrinol 166:291–294

    Article  PubMed  CAS  Google Scholar 

  • Wanders RJ, Komen JC (2007) Peroxisomes, Refsum’s disease and the alpha- and omega-oxidation of phytanic acid. Biochem Soc Trans 35:865–869

    Article  PubMed  CAS  Google Scholar 

  • Wichers-Rother M et al (2005) Adrenal steroids in adrenomyeloneuropathy. Dehydroepiandrosterone sulfate, androstenedione and 17alpha-hydroxyprogesterone. J Neurol 252:1525–1529

    Article  PubMed  CAS  Google Scholar 

  • Zhou Y, Lindberg I (1993) Purification and characterization of the prohormone convertase PC1(PC3). J Biol Chem 268:5615–5623

    PubMed  CAS  Google Scholar 

  • Zolman BK, Yoder A, Bartel B (2000) Genetic analysis of indole-3-butyric acid responses in Arabidopsis thaliana reveals four mutant classes. Genetics 156:1323–1337

    PubMed  CAS  Google Scholar 

  • Zolman BK, Nyberg M, Bartel B (2007) IBR3, a novel peroxisomal acyl-CoA dehydrogenase-like protein required for indole-3-butyric acid response. Plant Mol Biol 64:59–72

    Article  PubMed  CAS  Google Scholar 

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Acknowledgments

Dr. Isabelle Weinhofer is supported by an FWF Hertha Firnberg fellowship (T 562-B13).

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Authors and Affiliations

  1. Center for Brain Research, Medical University of Vienna, Spitalgasse 4, 1090, Vienna, Austria

    Isabelle Weinhofer, Markus Kunze, Sonja Forss-Petter & Johannes Berger

Authors
  1. Isabelle Weinhofer
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  2. Markus Kunze
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  3. Sonja Forss-Petter
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  4. Johannes Berger
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Corresponding author

Correspondence to Isabelle Weinhofer .

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Editors and Affiliations

  1. , Depto. Bioquímica, Biología Celular y, Estación Experimental del Zaidín, CSIC, Profesor Albareda 1, Granada, 18008, Spain

    Luis A. del Río

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Weinhofer, I., Kunze, M., Forss-Petter, S., Berger, J. (2013). Involvement of Human Peroxisomes in Biosynthesis and Signaling of Steroid and Peptide Hormones. In: del Río, L. (eds) Peroxisomes and their Key Role in Cellular Signaling and Metabolism. Subcellular Biochemistry, vol 69. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6889-5_6

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