The Philosophical Quest of a Cancer Cell: Redefining Existentialism

  • Ellora Sen


Poised in a seemingly prepared calm stasis with trust in the intangible, cancer cell makes decisions from a point where philosophy seems to be its major compass. As pure biological presuppositions cannot access or fathom this invisible philosophical realm of a cancer cell; syllogism rooted in scientific ratiocination alone without philosophical analysis will elude understanding of the objectivity of a cancer cell. Appreciation of this undiscovered unseen dimension (which is but a counterpart of the comprehensible visible), will unravel the deep interconnectedness between these two and provide insight far greater than empiric epistemology.


Tumor Microenvironment Ecological Niche System Participator Normative Notion Mere Reflection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



I thank editor Albrecht Reichle for giving me the opportunity for presenting the ideas that I have developed. His valuable suggestions, encouragement and unstinted support are gratefully acknowledged. I am thankful to my colleagues Anirban Basu, Sanchari Sinha and Sadashib Ghosh at the National Brain Research Centre for being loyal listeners of this philosophical analysis.


  1. 1.
    Spade V (1996) Jean-Paul Sartre’s Being and Nothingness, Class Lecture NotesGoogle Scholar
  2. 2.
    Camus A (1951) “The Rebel” translated from L’Homme revolteGoogle Scholar
  3. 3.
    Popper KR (1962) The open society and its enemies, vol I. In: The spell of PlatoGoogle Scholar
  4. 4.
    Dunn GP, Old LJ, Schreiber RD (2004) The immunobiology of cancer immunosurveillance and immunoediting. Immunity 21(2):137–148PubMedCrossRefGoogle Scholar
  5. 5.
    Germenis AE, Karanikas V (2007) Immunoepigenetics: the unseen side of cancer immunoediting. Immunol Cell Biol 85(1):55–59Google Scholar
  6. 6.
    Marusyk A, Polyak K (2010) Tumor heterogeneity: causes and consequences. Biochimica et biophysica acta 1805(1):105–117PubMedGoogle Scholar
  7. 7.
    Marusyk A, Almendro V, Polyak K (2012) Intra-tumour heterogeneity: a looking glass for cancer? Nat Rev Cancer 12(5):323–334PubMedCrossRefGoogle Scholar
  8. 8.
    Gerlinger M, Rowan AJ, Horswell S, et al (2012) Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. N Engl J Med 366(10):883–892PubMedCrossRefGoogle Scholar
  9. 9.
    Balkwill F, Mantovani A (2001) Inflammation and cancer: back to Virchow? Lancet 357(9255):539–545PubMedCrossRefGoogle Scholar
  10. 10.
    Mantovani A, Allavena P, Sica A, Balkwill F (2008) Cancer-related inflammation. Nature 454(7203):436–444PubMedCrossRefGoogle Scholar
  11. 11.
    Schafer M, Werner S (2008) Cancer as an overhealing wound: an old hypothesis revisited. Nat Rev Mol Cell Biol 9(8):628–638PubMedCrossRefGoogle Scholar
  12. 12.
    Dvorak HF (1986) Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. N Engl J Med 315(26):1650–1659PubMedCrossRefGoogle Scholar
  13. 13.
    Coussens LM, Werb Z (2002) Inflammation and cancer. Nature 420(6917):860–867PubMedCrossRefGoogle Scholar
  14. 14.
    Albini A, Sporn MB (2007) The tumour microenvironment as a target for chemoprevention. Nat Rev Cancer 7(2):139–147PubMedCrossRefGoogle Scholar
  15. 15.
    Bhatia S, Frangioni JV, Hoffman RM, Iafrate AJ, Polyak K (2012) The challenges posed by cancer heterogeneity. Nat Biotechnol 30(7):604–610PubMedCrossRefGoogle Scholar
  16. 16.
    Polyak K, Haviv I, Campbell IG (2009) Co-evolution of tumor cells and their microenvironment. Trends Genet 25(1):30–380PubMedCrossRefGoogle Scholar
  17. 17.
    Chen JL, Lucas JE, Schroeder T, et al (2008) The genomic analysis of lactic acidosis and acidosis response in human cancers. PLoS Genet 4(12):e1000293Google Scholar
  18. 18.
    Gatenby RA, Gillies RJ, Brown JS (2010) Evolutionary dynamics of cancer prevention. Nat Rev 10(8):526–527CrossRefGoogle Scholar
  19. 19.
    Gatenby RA, Gillies RJ (2008) A microenvironmental model of carcinogenesis. Nat Rev 8(1):56–61CrossRefGoogle Scholar
  20. 20.
    Jones RJ, Matsui WH, Smith BD (2004) Cancer stem cells: are we missing the target? J Nat Cancer Inst 96(8):583–585PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  1. 1.National Brain Research CentreManesarIndia

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