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The History, Principles, and Practice of Parenteral Nutrition in Preterm Neonates

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Nutrition for the Preterm Neonate

Abstract

The history of the successful development of Total Parenteral Nutrition (TPN), first in beagle puppies in the basic science laboratories, and its subsequent clinical translations initially to adults, and shortly thereafter, to a newborn infant, is recounted by the original developer of the techniques, data, and results that have led to its widespread application and acceptance throughout the world. The principles, practices, standards, techniques, observations, technology, and several of the countless details which were so essential in guiding this dream to reality, are woven throughout the narrative. The advances and milestones are traced along this passionate, relentless journey to the present day, when preterm infants are actually expected to live and thrive. The precision and conscientious attention which are essential to the judicious, safe, efficacious use of TPN in preterm neonates throughout all aspects of solution formulation and delivery, together with appropriate monitoring and assessment of outcomes, are described and discussed briefly. The multiple risks and complications associated with this complex life-saving technique are extensively tabulated, with the intention to teach, in order to avoid, prevent, or overcome them. Moreover, attention has been directed toward pointing out many of the persisting shortcomings of the technique which remain to be prevented, overcome, or corrected by future research efforts and experiences. Finally, the costs, philosophy, humanity, and future advancements necessary to apply TPN to the care of preterm infants in developing countries are stated with optimism and hope.

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Correspondence to Stanley J. Dudrick MD, FACS, FACN, CNS .

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Dudrick, S., Malkan, A. (2013). The History, Principles, and Practice of Parenteral Nutrition in Preterm Neonates. In: Patole, S. (eds) Nutrition for the Preterm Neonate. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6812-3_10

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