Host Molecular Chaperones: Cell Surface Receptors for Viruses
Molecular chaperones play important roles in maintaining cellular homeostasis under normal conditions. They also participate in a post-translational quality control system, maintaining the correct conformation of proteins under changing environmental conditions. While most molecular chaperones localize in the cytosol, some can exist outside the cell and are involved in moonlighting activities. It has been reported that some molecular chaperones at the cell surface act as receptors for viruses. Viruses using molecular chaperones as their receptors take advantage of these molecules to enable efficient introduction of their genomes into the cell and/or for selection of favorable target cells and of replication-competent virions.
KeywordsLipid Raft Molecular Chaperone Japanese Encephalitis Virus Measle Virus Virus Entry
This work was supported by Grants-in-Aid for Young Scientists (KAKENHI) from Japan Society for the Promotion of Science (JSPS) (JSPS KAKENHI Grant Numbers 23790496 and 25860336 T.H.), and Funding Program for Next Generation World-Leading Researchers (NEXT program) from JSPS (K.T.).
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