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Transcriptional Control of Epidermal Stem Cells

  • Briana Lee
  • Xing DaiEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 786)

Abstract

Transcriptional regulation is fundamentally important for the progression of tissue stem cells through different stages of development and differentiation. Mammalian skin epidermis is an excellent model system to study such regulatory mechanisms due to its easy accessibility, stereotypic spatial arrangement, and availability of well-established cell type/lineage differentiation markers. Moreover, epidermis is one of the few mammalian tissues the stem cells of which can be maintained and propagated in culture to generate mature cell types and a functional tissue (reviewed in [1]), offering in vitro and ex vivo platforms to probe deep into the underlying cell and molecular mechanisms of biological functions.

Keywords

Epidermis Hair follicle Stem cell Transcription factor Chromatin regulation 

Abbreviations

BrdU

Bromodeoxyuridine

DNMT

DNA Methyltransferase

EGF

Epidermal Growth Factor

EMT

Epithelial-To-Mesenchymal Transition

FACS

Fluorescence Activated Cell Sorting

GFP

Green Fluorescent Protein

H3K27

Histone H3 Lysine 27

HDAC

Histone Deacetylase

IFE

Interfollicular Epidermis

K

Keratin

LRC

Label Retaining Cell

NICD

Notch Intracellular Domain

ORS

Outer Root Sheath

PcG

Polycomb Group Proteins

SC

Stem Cell

Shh

Sonic hedgehog

TA

Transit Amplifying

HG

Secondary Hair Germ

Notes

Acknowledgements

We apologize to colleagues whose work is not cited due to space limitation. Work on Ovol in the Dai laboratory has been supported by NIH Grants R01-AR47320 and K02-AR51482 (to X.D.). Briana Lee acknowledges predoctoral research support from the Systems Biology of Development (HD060555) and Translational Research in Cancer Genomic Medicine (CA113265) NIH Training Grants.

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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  1. 1.Department of Biological Chemistry, School of MedicineUniversity of CaliforniaIrvineUSA

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