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Myc in Stem Cell Behaviour: Insights from Drosophila

  • Leonie M. QuinnEmail author
  • Julie Secombe
  • Gary R. Hime
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 786)

Abstract

The Myc family proteins are key regulators of animal growth and development, which have critical roles in modulating stem cell behaviour. Since the identification of the oncogenic potential of c-Myc in the early 1980s the mammalian Myc family, which is comprised of c-Myc, N-Myc, and L-Myc, has been studied extensively. dMyc, the only Drosophila member of the Myc gene family, is orthologous to the mammalian c-Myc oncoprotein. Here we discuss key studies addressing the function of the Myc family in stem cell behaviour in both Drosophila Models and mammalian systems.

Keywords

Myc Drosophila Cell growth Cell cycle Stem cells Cancer 

Notes

Acknowledgements

Thanks to Bob Eisenman and David Stein for the dMyc antibodies and to the Vienna Drosophila Research Centre (VDRC) for the dMyc RNAi lines. This work was supported by grants from the National Health and Medical Research Council (NHMRC).

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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Leonie M. Quinn
    • 1
    Email author
  • Julie Secombe
    • 2
  • Gary R. Hime
    • 1
  1. 1.Department of Anatomy and NeuroscienceUniversity of MelbourneParkville, MelbourneAustralia
  2. 2.Department of GeneticsAlbert Einstein College of MedicineBronx, New YorkUSA

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