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JAK-STAT Signaling in Stem Cells

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Transcriptional and Translational Regulation of Stem Cells

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 786))

Abstract

Adult stem cells are essential for the regeneration and repair of tissues in an organism. Signals from many different pathways converge to regulate stem cell maintenance and differentiation while preventing overproliferation. Although each population of adult stem cells is unique, common themes arise by comparing the regulation of various stem cell types in an organism or by comparing similar stem cell types across species. The JAK-STAT signaling pathway, identified nearly two decades ago, is now known to be involved in many biological processes including the regulation of stem cells. Studies in Drosophila first implicated JAK-STAT signaling in the control of stem cell maintenance in the male germline stem cell microenvironment, or niche; subsequently it has been shown play a role in other niches in both Drosophila and mammals. In this chapter, we will address the role of JAK-STAT signaling in stem cells in the germline, intestinal, hematopoietic and neuronal niches in Drosophila as well as the hematopoietic and neuronal niches in mammals. We will comment on how the study of JAK-STAT signaling in invertebrate systems has helped to advance our understanding of signaling in vertebrates. In addition to the role of JAK- STAT signaling in stem cell niche homeostasis, we will also discuss the diseases, including cancers, that can arise when this pathway is misregulated.

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  1. Department of Cell Biology, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD, 21205, USA

    Rachel R. Stine & Erika L. Matunis

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  1. Rachel R. Stine
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  2. Erika L. Matunis
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Correspondence to Erika L. Matunis .

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  1. , Anatomy and Neuroscience, University of Melbourne, VIC Grattan Street, Parkville, 3010, Victoria, Australia

    Gary Hime

  2. , Anatomy and Developmental Biology, Monash University, Monash University, Clayton, 3800, Victoria, Australia

    Helen Abud

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Stine, R.R., Matunis, E.L. (2013). JAK-STAT Signaling in Stem Cells. In: Hime, G., Abud, H. (eds) Transcriptional and Translational Regulation of Stem Cells. Advances in Experimental Medicine and Biology, vol 786. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-6621-1_14

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