The Stem Cell State
This volume describes the latest findings on transcriptional and translational regulation of stem cells. Both transcriptional activators and repressors have been shown to be crucial for the maintenance of the stem cell state. A key element of stem cell maintenance is repression of differentiation factors or developmental genes – achieved transcriptionally, epigenetically by the Polycomb complex, and post-transcriptionally by RNA-binding proteins and microRNAs. This volume takes two approaches to this topic – (1) illustrating the general principles outlined above through a series of different stem cell examples – embryonic, iPS and adult stem cells, and (2) describing several molecular families that have been shown to have roles in regulation of multiple stem cell populations.
KeywordsClonogenicity History Niche Pluripotency Repression
- 1.Driesch H (1892) The potency of the first two cleavage cells in echinoderm development. Experimental production of partial and double formation (reprinted translation). In: Oppenheimer JM (ed) Foundations of experimental embryology, part 2. Hafner, New York, pp 39–50Google Scholar
- 7.Spemann H (1938) Embryonic development and induction. Yale University Press, New HavenGoogle Scholar
- 10.Maximow A (1909) The lymphocyte as a stem cell common to different blood elements in embryonic development and during the post-fetal life of mammals. Originally in German. Folia Haematol 8:125–134 [English translation (2009) Cell Ther Transplant 1(3):14–18]Google Scholar