Neuroblastoma: Inhibition by Alu-Like RNA

  • Manuele Castelnuovo
  • Tullio Florio
  • Giorgio Dieci
  • Ranieri Cancedda
  • Aldo Pagano
Part of the Pediatric Cancer book series (PECA, volume 4)


Neuroblastoma (NB) is one of the most frequent pediatric solid tumors characterized by remarkable cell heterogeneity within the cancer nodules. We have recently documented that the synthesis of a pol III-transcribed non-coding (nc) RNA (NDM29) strongly restricts NB development by promoting cell differentiation, a drop of malignancy processes and a dramatic reduction of the tumor initiating cells (TICs) fraction in the NB cell population. Importantly, the overexpression of NDM29 also confers to malignant NB cells an unpredicted susceptibility to the effects of antiblastic drugs used in NB therapy. Thus, treatments able to induce NDM29 expression within cancer cells, making the elusive cancer stem cells more vulnerable to the anticancer drugs, may be used synergistically with traditional cytotoxic therapy to obtain a more complete tumor eradication.


Transcription Unit Cancer Nodule HeLa Cell Nuclear Extract Upstream Promoter Element Proximal Sequence Element 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Manuele Castelnuovo
    • 1
  • Tullio Florio
    • 1
  • Giorgio Dieci
    • 1
  • Ranieri Cancedda
    • 1
  • Aldo Pagano
    • 1
  1. 1.Department of Experimental Medicine (DiMES)University of Genoa and IRCCS-AOU San Martino-ISTGenovaItaly

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