Pediatric Lymphoma Patients: Cytomegalovirus Infection

  • Samah A. Loutfy
Part of the Pediatric Cancer book series (PECA, volume 4)


Cancer care has improved and intensified over recent decades, and as patients with cancer survive longer, various infectious complications have been more pronounced. Pediatric cancer patients are at high risk of infectious complications because they are immunologically immature. Human cytomegalovirus (HCMV) is a persistent pathogen, can cause life threatening infection in immunocompromised patients, such as bone marrow and organ transplant recipients, ­persons with AIDS, and patients with hematological malignancies (leukemias and ­lymphomas). Despite Previous studies before application of sensitive molecular methods, demonstrated association of CMV with fever and hepatitis in children with malignancy, CMV has not been extensively studied in pediatric cancer patients. Very limited data are available in the literatures related to symptomatic CMV infection and its clinical relevance on outcome of diseases in pediatric cancer patients especially children with hematological malignancies. These studies are relevant as new advanced diagnostic techniques are now available for detection of the virus in different clinical specimens, ­new advances in the management of CMV infection and disease have been developed, and the performance of prospective clinical trails of antiviral agents has been evaluated. Therefore, the aim of this review is to shade a light on some of these data that are available in the literatures, and relevance of future studies concerned activity of CMV in pediatric lymphoma patients.


Hematological Malignancy Lymphoma Patient Pediatric Cancer Patient High Apache Antigenemia Assay 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  1. 1.Virology and Immunology, Cancer Biology Department, National Cancer InstituteCairo UniversityGizaEgypt

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