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The Electrical Regulation of GI Motility at the Whole-Organ Level

  • Timothy R. Angeli
  • Gregory O’Grady
  • Wim J. E. P. Lammers
Chapter
Part of the Lecture Notes in Computational Vision and Biomechanics book series (LNCVB, volume 10)

Abstract

A rhythmic bioelectrical activity, composed of slow waves and spikes, plays a central role in coordinating contractions in much of the gastrointestinal tract. This chapter addresses the current state of knowledge of the electrical activity contributing to the regulation of GI contractions, with a specific focus on organ-level excitation in the stomach and small intestine. Emphasis is placed on data obtained from extracellular recordings, which effectively profile patterns of bioelectrical propagation over large tissue scales. Recent advances in understanding whole-organ excitation from high-resolution (HR) electrical mapping studies are discussed in particular detail. Lastly, clinical and research questions of current interest are identified.

Keywords

Slow Wave Slow Wave Activity Migrate Motor Complex Gastric Slow Wave Gastric Dysrhythmia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

TRA is supported by the Riddet Institute, the Royal Society of NZ, and the NZ Society of Gastroenterology. GOG is supported by the American Neurogastroenterology & Motility Society, the NZ Health Research Council, and the NIH (R01 DK64775).

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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Timothy R. Angeli
    • 1
    • 2
  • Gregory O’Grady
    • 1
    • 3
  • Wim J. E. P. Lammers
    • 4
    • 1
  1. 1.Auckland Bioengineering InstituteUniversity of AucklandAucklandNew Zealand
  2. 2.Riddet InstitutePalmerston NorthNew Zealand
  3. 3.Department of SurgeryUniversity of AucklandAucklandNew Zealand
  4. 4.Department of PhysiologyUAE UniversityAl AinUnited Arab Emirates

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